Potential therapeutic targets shared between leishmaniasis and cancer
Keywords: 
Cancer
Common protein
Drug
Leishmaniasis
Therapeutic target
Issue Date: 
2021
Publisher: 
Cambridge University Press
ISSN: 
0031-1820
Note: 
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence
Citation: 
Rashidi, S. (Sajad); Fernández-Rubio, C. (Celia); Manzano-Román, R. (Raúl); et al. "Potential therapeutic targets shared between leishmaniasis and cancer". Parasitology. (148), 2021, 655 - 671
Abstract
The association of leishmaniasis and malignancies in human and animal models has been highlighted in recent years. The misdiagnosis of coexistence of leishmaniasis and cancer and the use of common drugs in the treatment of such diseases prompt us to further survey the molecular biology of Leishmania parasites and cancer cells. The information regarding common expressed proteins, as possible therapeutic targets, in Leishmania parasites and cancer cells is scarce. Therefore, the current study reviews proteins, and investigates the regulation and functions of several key proteins in Leishmania parasites and cancer cells. The up- and down-regulations of such proteins were mostly related to survival, development, pathogenicity, metabolic pathways and vital signalling in Leishmania parasites and cancer cells. The presence of common expressed proteins in Leishmania parasites and cancer cells reveals valuable information regarding the possible shared mechanisms of pathogenicity and opportunities for therapeutic targeting in leishmaniasis and cancers in the future.

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