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dc.creatorAhechu-Garayoa, P. (Patricia)-
dc.creatorZozaya, G. (Gabriel)-
dc.creatorMarti, P. (Pablo)-
dc.creatorHernandez-Lizoain, J.L. (Jose Luis)-
dc.creatorBaixauli, J. (Jorge)-
dc.creatorUnamuno, X. (Xabier)-
dc.creatorFrühbeck, G. (Gema)-
dc.creatorCatalan, V. (Victoria)-
dc.date.accessioned2022-10-06T07:41:57Z-
dc.date.available2022-10-06T07:41:57Z-
dc.date.issued2018-
dc.identifier.citationAhechu-Garayoa, P. (Patricia); Zozaya, G. (Gabriel); Marti, P. (Pablo); et al. "NLRP3 inflammasome: a possible link between obesity-associated low-grade chronic inflammation and colorectal cancer development". . 9, 2018, 2918es_ES
dc.identifier.issn1664-3224-
dc.identifier.urihttps://hdl.handle.net/10171/64379-
dc.description.abstractEmerging evidence reveals that adipose tissue-associated inflammation is a main mechanism whereby obesity promotes colorectal cancer risk and progression. Increased inflammasome activity in adipose tissue has been proposed as an important mediator of obesity-induced inflammation and insulin resistance development. Chronic inflammation in tumor microenvironments has a great impact on tumor development and immunity, representing a key factor in the response to therapy. In this context, the inflammasomes, main components of the innate immune system, play an important role in cancer development showing tumor promoting or tumor suppressive actions depending on the type of tumor, the specific inflammasome involved, and the downstream effector molecules. The inflammasomes are large multiprotein complexes with the capacity to regulate the activation of caspase-1. In turn, caspase-1 enhances the proteolytic cleavage and the secretion of the inflammatory cytokines interleukin (IL)-1 beta and IL-18, leading to infiltration of more immune cells and resulting in the generation and maintenance of an inflammatory microenvironment surrounding cancer cells. The inflammasomes also regulate pyroptosis, a rapid and inflammation-associated form of cell death. Recent studies indicate that the inflammasomes can be activated by fatty acids and high glucose levels linking metabolic danger signals to the activation of inflammation and cancer development. These data suggest that activation of the inflammasomes may represent a crucial step in the obesity-associated cancer development. This review will also focus on the potential of inflammasome-activated pathways to develop new therapeutic strategies for the prevention and treatment of obesity-associated colorectal cancer development.es_ES
dc.description.sponsorshipThis work was supported by ISCIII-Subdirección General de Evaluación y FEDER (PI17/02188; Plan Estatal I + D + I/2013-2016). CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN) is an initiative of the ISCIII, Spain.es_ES
dc.language.isoenges_ES
dc.publisherNCBIes_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectInflammasomees_ES
dc.subjectNlrp3es_ES
dc.subjectInflammationes_ES
dc.subjectColon canceres_ES
dc.subjectObesityes_ES
dc.subjectAdipose tissuees_ES
dc.subjectImmunityes_ES
dc.titleNLRP3 inflammasome: a possible link between obesity-associated low-grade chronic inflammation and colorectal cancer developmentes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.description.noteThis is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.es_ES
dc.identifier.doi10.3389/fimmu.2018.02918-
dadun.citation.startingPage2918es_ES
dadun.citation.volume9es_ES

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