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dc.creatorFernandez-Robredo, P. (Patricia)-
dc.creatorRecalde, S. (Sergio)-
dc.creatorHernandez, M. (María)-
dc.creatorZarranz-Ventura, J. (Javier)-
dc.creatorMolins, B. (Blanca)-
dc.creatorCasaroli-Marano, R. (Ricardo)-
dc.creatorAdan, A. (Alfredo)-
dc.creatorSaenz-de-Viteri, M. (Manuel)-
dc.creatorGarcia-Layana, A. (Alfredo)-
dc.date.accessioned2022-10-06T07:59:56Z-
dc.date.available2022-10-06T07:59:56Z-
dc.date.issued2018-
dc.identifier.citationFernandez-Robredo, P. (Patricia); Recalde, S. (Sergio); Hernandez, M. (María); et al. "Novel association of high C-reactive protein levels and A69S at risk alleles in wet age-related macular degeneration women". FRONTIERS IN IMMUNOLOGY. 9, 2018, 1862es_ES
dc.identifier.issn1664-3224-
dc.identifier.urihttps://hdl.handle.net/10171/64384-
dc.description.abstractPurpose: To explore the relationship between plasma C-reactive protein (CRP) levels, the main ARMS2 gene single nucleotide polymorphism (SNP), and gender in patients with neovascular age-related macular degeneration (wet AMD). Methods: Our study included 131 patients with wetAMD [age-related eye disease study (AREDS) category 4] and 153 control participants (AREDS category 1) from two Spanish retinal units. CRP levels were determined on blood samples by high-sensitivity ELISA assay. According to their CRP level, subjects were categorized into three well-established CRP categories: low (<1.00 mg/L, L-CRP), moderate (1-2.99 mg/L, M-CRP), and high (>3.00 mg/L, H-CRP). Genomic DNA was extracted from oral swabs using QIAcube (Qiagen, Hilden, Germany) and the A69S; rs10490924 of ARMS2 gene was genotyped by allelic discrimination with validated TaqMan assays (Applied Biosystems, Foster City, CA, USA). Univariate and multivariate logistic regression adjusted for age was used to analyze the genomic frequencies and to calculate odds ratio (OR) using SNPStats software. Results: Considering CRP risk categories, H-CRP group showed a significant [OR 4.0 (1.9-8.3)] association with wetAMD compared to L-CRP group. The risk genotypes of A69S (TT) SNPs showed an association with wetAMD risk [OR 14.0 (4.8-40.8)]. Interestingly, the gender stratification of the CRP categories showed a significant increase in CRP levels in wetAMD women compared with control women [OR 6.9 (2.2-22.3)] and with wetAMD men [OR 4.6 (1.3-16.9)]. In addition, the subgroup analysis of CRP within A69S genotype and gender showed a link in women between the A69S and CRP levels in the AMD group compared to controls [OR 4.2 (1.4-12.6)]. Conclusion: Our study shows, for the first time, that a different genetic association related with gender could contribute to AMD risk. As a consequence, the risk of female gender in the different CRP levels and A69S SNP frequencies could be taken into consideration to the established risk relationship of high levels of CRP and its association with risk A69S genotype.es_ES
dc.description.sponsorshipSpanish Multicenter Group on AMD and the “Red Temática de Investigación Cooperativa en Salud” OFTARED RD12/0034 and RD16/0008es_ES
dc.language.isoenges_ES
dc.publisherFrontierses_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectC-reactive proteines_ES
dc.subjectCase–control studieses_ES
dc.subjectGender differenceses_ES
dc.subjectPolymorphismes_ES
dc.subjectSingle nucleotidees_ES
dc.subjectWet macular degenerationes_ES
dc.titleNovel association of high C-reactive protein levels and A69S at risk alleles in wet age-related macular degeneration womenes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.description.noteThis is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.es_ES
dc.identifier.doi10.3389/fimmu.2018.01862-
dadun.citation.publicationNameFRONTIERS IN IMMUNOLOGYes_ES
dadun.citation.startingPage1862es_ES
dadun.citation.volume9es_ES

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