Optimal experimental design for cytogenetic dose-response calibration curves
Keywords: 
Biodosimetry
I-optimality
Calibration
Issue Date: 
30-Mar-2020
Citation: 
Higueras M, Howes A, López-Fidalgo J. Optimal experimental design for cytogenetic dose-response calibration curves. Int J Radiat Biol. 2020 Jul;96(7):894-902. doi: 10.1080/09553002.2020.1741719.
Abstract
Purpose: To introduce optimal experimental design techniques in the cytogenetic biological dosimetry practice. This includes the development of a new optimatility criterion for the calibration of radiation doses. Materials and Methods: The most typical optimal design criterion and the one developed in this research are introduced and applied in an example from the litera- ture. In another example from the literature, a simulation study has been performed to compare the standard error of the dose estimation using di erent experimental designs. An RStudio project and a GitHub project have been developed to repro- duce these results. Results: It is appreciated how the application of optimal experimental design tech- niques can reduce the standard error of biodosimetric dose estimations. Conclusions: Optimal experimental design techniques jointly with practitioners re- quirements may be applied. This practice would not involve an additional laboratory work.
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