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DC Field | Value | Language |
---|---|---|
dc.creator | Higueras, M. (Manuel) | - |
dc.creator | Howes, A. (Adam) | - |
dc.creator | López-Fidalgo, J. (Jesús) | - |
dc.date.accessioned | 2022-10-17T07:24:02Z | - |
dc.date.available | 2022-10-17T07:24:02Z | - |
dc.date.issued | 2020-03-30 | - |
dc.identifier.citation | Higueras M, Howes A, López-Fidalgo J. Optimal experimental design for cytogenetic dose-response calibration curves. Int J Radiat Biol. 2020 Jul;96(7):894-902. doi: 10.1080/09553002.2020.1741719. | es_ES |
dc.identifier.uri | https://hdl.handle.net/10171/64431 | - |
dc.description.abstract | Purpose: To introduce optimal experimental design techniques in the cytogenetic biological dosimetry practice. This includes the development of a new optimatility criterion for the calibration of radiation doses. Materials and Methods: The most typical optimal design criterion and the one developed in this research are introduced and applied in an example from the litera- ture. In another example from the literature, a simulation study has been performed to compare the standard error of the dose estimation using di erent experimental designs. An RStudio project and a GitHub project have been developed to repro- duce these results. Results: It is appreciated how the application of optimal experimental design tech- niques can reduce the standard error of biodosimetric dose estimations. Conclusions: Optimal experimental design techniques jointly with practitioners re- quirements may be applied. This practice would not involve an additional laboratory work. | es_ES |
dc.description.sponsorship | This work was supported the Basque Government under Grant BERC 360 2014-2017; the Spanish Ministry of Economy and Competitiveness MINECO and FEDER under Grant BCAM Severo Ochoa excellence accreditation SEV-2017-0718; BIOSTATNET under 2014 and 2016 calls for Programa de estancias BIOSTATNET j ovenes investi- gadores; the Spanish Research Agency and fondos FEDER under Grants MTM2013- 47879-C2-1-P and MTM2016-80539-C2-R1. | es_ES |
dc.language.iso | eng | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Biodosimetry | es_ES |
dc.subject | I-optimality | es_ES |
dc.subject | Calibration | es_ES |
dc.title | Optimal experimental design for cytogenetic dose-response calibration curves | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.identifier.doi | 10.1080/09553002.2020.1741719 | - |
dadun.citation.endingPage | 902 | es_ES |
dadun.citation.number | 7 | es_ES |
dadun.citation.publicationName | International Journal of Radiation Biology | es_ES |
dadun.citation.startingPage | 894 | es_ES |
dadun.citation.volume | 96 | es_ES |
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