Full metadata record
DC Field | Value | Language |
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dc.creator | Hernáez, Á. (Álvaro) | - |
dc.creator | Castañer, O. (Olga) | - |
dc.creator | Tresserra-Rimbau, A. (Anna) | - |
dc.creator | Pinto, X. (Xavier) | - |
dc.creator | Fito, M. (Montserrat) | - |
dc.creator | Casas, R. (Rosa) | - |
dc.creator | Martinez-Gonzalez, M.A. (Miguel Ángel) | - |
dc.creator | Corella, D. (Dolores) | - |
dc.creator | Salas-Salvado, J. (Jordi) | - |
dc.creator | Lapetra, J. (José) | - |
dc.creator | Gomez-Gracia, E. (Enrique) | - |
dc.creator | Aros, F. (Fernando) | - |
dc.creator | Fiol, M. (Miquel) | - |
dc.creator | Serra-Majem, L. (Luis) | - |
dc.creator | Ros, E. (Emilio) | - |
dc.creator | Estruch, R. (Ramón) | - |
dc.date.accessioned | 2022-10-17T11:59:04Z | - |
dc.date.available | 2022-10-17T11:59:04Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | Hernáez Á, Castañer O, Tresserra-Rimbau A, Pintó X, Fitó M, Casas R, Martínez-González MÁ, Corella D, Salas-Salvadó J, Lapetra J, Gómez-Gracia E, Arós F, Fiol M, Serra-Majem L, Ros E, Estruch R. Mediterranean Diet and Atherothrombosis Biomarkers: A Randomized Controlled Trial. Mol Nutr Food Res. 2020 Oct;64(20):e2000350. doi: 10.1002/mnfr.202000350. | es_ES |
dc.identifier.uri | https://hdl.handle.net/10171/64436 | - |
dc.description.abstract | Scope. To assess whether following a Mediterranean diet (MedDiet) improved atherothrombosis biomarkers in high cardiovascular risk individuals. Methods and results. In 358 random volunteers from the PREvención con DIeta MEDiterránea trial, we assessed the 1-year effects on atherothrombosis markers of an intervention with MedDiet, enriched with virgin olive oil (MedDiet-VOO; n=120) or nuts (MedDiet-Nuts; n=119) versus a low-fat control diet (n=119). We also studied whether large increments in MedDiet adherence (≥3 score points, relative to compliance decreases) and intake changes in key food items were associated with 1-year differences in biomarkers. We observed differences between 1-year changes in the MedDiet-VOO intervention and control diet on the activity of platelet activating factor acetylhydrolase in HDLs (+7.5% [95% confidence interval: 0.17; 14.8]) and HDL-bound α1-antitrypsin levels (- 6.1% [-11.8; -0.29]), and between the MedDiet-Nuts intervention and the control arm on non-esterified fatty acid concentrations (-9.3% [-18.1; -0.53]). Large MedDiet adherence increments were associated with less fibrinogen (-9.5% [-18.3; -0.60]) and non-esterified fatty acid concentrations (-16.7% [-31.7; -1.74]). Increases in nut, fruit, vegetable, and fatty fish consumption, and decreases in processed meat intake were linked to beneficial changes in atherothrombosis biomarkers. Conclusion. Following a MedDiet improved atherothrombosis biomarkers in high cardiovascular risk individuals | es_ES |
dc.description.sponsorship | This work was supported by grants of Instituto de Salud Carlos III [OBN17PI02, PIE14/00045_INFLAMES, CB06/03/0019, CB06/03/0028, and CD17/00122 (A.H.)], and Agència de Gestió d’Ajuts Universitaris i de Recerca (2017 SGR 222). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | John Wiley & Sons | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Atherothrombosis | es_ES |
dc.subject | Biomarkers | es_ES |
dc.subject | Cardiovascular risks | es_ES |
dc.subject | Clinical trials | es_ES |
dc.subject | Mediterranean diet | es_ES |
dc.title | Mediterranean Diet and atherothrombosis biomarkers: a randomized controlled trial | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dadun.citation.number | 20 | es_ES |
dadun.citation.publicationName | Molecular Nutrition and Food Research | es_ES |
dadun.citation.volume | 64 | es_ES |
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