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dc.creatorHernáez, Á. (Álvaro)-
dc.creatorCastañer, O. (Olga)-
dc.creatorTresserra-Rimbau, A. (Anna)-
dc.creatorPinto, X. (Xavier)-
dc.creatorFito, M. (Montserrat)-
dc.creatorCasas, R. (Rosa)-
dc.creatorMartinez-Gonzalez, M.A. (Miguel Ángel)-
dc.creatorCorella, D. (Dolores)-
dc.creatorSalas-Salvado, J. (Jordi)-
dc.creatorLapetra, J. (José)-
dc.creatorGomez-Gracia, E. (Enrique)-
dc.creatorAros, F. (Fernando)-
dc.creatorFiol, M. (Miquel)-
dc.creatorSerra-Majem, L. (Luis)-
dc.creatorRos, E. (Emilio)-
dc.creatorEstruch, R. (Ramón)-
dc.identifier.citationHernáez Á, Castañer O, Tresserra-Rimbau A, Pintó X, Fitó M, Casas R, Martínez-González MÁ, Corella D, Salas-Salvadó J, Lapetra J, Gómez-Gracia E, Arós F, Fiol M, Serra-Majem L, Ros E, Estruch R. Mediterranean Diet and Atherothrombosis Biomarkers: A Randomized Controlled Trial. Mol Nutr Food Res. 2020 Oct;64(20):e2000350. doi: 10.1002/mnfr.202000350.es_ES
dc.description.abstractScope. To assess whether following a Mediterranean diet (MedDiet) improved atherothrombosis biomarkers in high cardiovascular risk individuals. Methods and results. In 358 random volunteers from the PREvención con DIeta MEDiterránea trial, we assessed the 1-year effects on atherothrombosis markers of an intervention with MedDiet, enriched with virgin olive oil (MedDiet-VOO; n=120) or nuts (MedDiet-Nuts; n=119) versus a low-fat control diet (n=119). We also studied whether large increments in MedDiet adherence (≥3 score points, relative to compliance decreases) and intake changes in key food items were associated with 1-year differences in biomarkers. We observed differences between 1-year changes in the MedDiet-VOO intervention and control diet on the activity of platelet activating factor acetylhydrolase in HDLs (+7.5% [95% confidence interval: 0.17; 14.8]) and HDL-bound α1-antitrypsin levels (- 6.1% [-11.8; -0.29]), and between the MedDiet-Nuts intervention and the control arm on non-esterified fatty acid concentrations (-9.3% [-18.1; -0.53]). Large MedDiet adherence increments were associated with less fibrinogen (-9.5% [-18.3; -0.60]) and non-esterified fatty acid concentrations (-16.7% [-31.7; -1.74]). Increases in nut, fruit, vegetable, and fatty fish consumption, and decreases in processed meat intake were linked to beneficial changes in atherothrombosis biomarkers. Conclusion. Following a MedDiet improved atherothrombosis biomarkers in high cardiovascular risk individualses_ES
dc.description.sponsorshipThis work was supported by grants of Instituto de Salud Carlos III [OBN17PI02, PIE14/00045_INFLAMES, CB06/03/0019, CB06/03/0028, and CD17/00122 (A.H.)], and Agència de Gestió d’Ajuts Universitaris i de Recerca (2017 SGR 222).es_ES
dc.publisherJohn Wiley & Sonses_ES
dc.subjectCardiovascular riskses_ES
dc.subjectClinical trialses_ES
dc.subjectMediterranean dietes_ES
dc.titleMediterranean Diet and atherothrombosis biomarkers: a randomized controlled triales_ES
dadun.citation.publicationNameMolecular Nutrition and Food Researches_ES

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