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dc.creatorSánchez-Quesada, C. (Cristina)-
dc.creatorLópez-Biedma, A. (Alicia)-
dc.creatorToledo, E. (Estefanía)-
dc.creatorGaforio, J.J. (José Juan)-
dc.date.accessioned2022-10-19T10:23:36Z-
dc.date.available2022-10-19T10:23:36Z-
dc.date.issued2018-
dc.identifier.citationSánchez-Quesada, C. (Cristina); López-Biedma, A. (Alicia); Toledo, E. (Estefanía); et al. "Squalene stimulates a key innate immune cell to foster wound healing and tissue repair". Evidence-based complementary and alternative medicine. 2018, 2018, 9473094es_ES
dc.identifier.issn1741-427X-
dc.identifier.urihttps://hdl.handle.net/10171/64512-
dc.description.abstractAnti-inflammatory effects of virgin olive oil (VOO) have been described recently, along with its wound healing effect. One of the main minor compounds found in VOO is squalene (SQ), which also possesses preventive effects against skin damage and anti-inflammatory properties. The inflammatory response is involved in wound healing and manages the whole process by macrophages, among others, as the main innate cells with a critical role in the promotion and resolution of inflammation for tissue repair. Because of that, this work is claimed to describe the role that squalene exerts in the immunomodulation of M1 proinflammatory macrophages, which are the first cells implicate in recent injuries. Pro- and anti-inflammatory cytokines were analysed using TPH1 cell experimental model. SQ induced an increase in the synthesis of anti-inflammatory cytokines, such as IL-10, IL-13, and IL-4, and a decrease in proinflammatory signals, such as TNF-α and NF-κB in M1 proinflammatory macrophages. Furthermore, SQ enhanced remodelling and repairing signals (TIMP-2) and recruitment signals of eosinophils and neutrophils, responsible for phagocytosis processes. These results suggest that SQ is able to promote wound healing by driving macrophage response in inflammation. Therefore, squalene could be useful at the resolution stage of wound healing.es_ES
dc.description.sponsorshipTis work was supported by the “Junta de Andalucia” (Proyecto de Excelencia PI10-AGR-6724).es_ES
dc.language.isoenges_ES
dc.publisherHindawies_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectVirgin olive oil (VOO)es_ES
dc.subjectSqualenees_ES
dc.subjectWound healinges_ES
dc.titleSqualene stimulates a key innate immune cell to foster wound healing and tissue repaires_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.description.noteTis is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.es_ES
dc.identifier.doi10.1155/2018/9473094-
dadun.citation.publicationNameEvidence-based complementary and alternative medicinees_ES
dadun.citation.startingPage9473094es_ES
dadun.citation.volume2018es_ES

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