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dc.creatorCantero-González, I. (Irene)-
dc.creatorAbete, I. (Itziar)-
dc.creatorBas, J.M. (Josep Maria) del-
dc.creatorCaimari, A. (Antoni)-
dc.creatorZulet, M.A. (María Ángeles)-
dc.creatorMartinez, J.A. (José Alfredo)-
dc.date.accessioned2022-10-19T10:46:23Z-
dc.date.available2022-10-19T10:46:23Z-
dc.date.issued2018-
dc.identifier.citationCantero-González, I. (Irene); Abete, I. (Itziar); Bas, J.M. (Josep Maria) del; et al. "Changes in lysophospholipids and liver status after weight loss: the RESMENA study". NUTRITION AND METABOLISM. 15, 2018, 51es_ES
dc.identifier.issn1743-7075-
dc.identifier.urihttps://hdl.handle.net/10171/64522-
dc.description.abstractBackground: Obesity and comorbidities such as non-alcoholic fatty liver disease (NAFLD) are major public health burdens. Alterations in lipid metabolism are involved in hepatic diseases. The objective of this study was to assess the influence of weight loss on lysophospholipid (LP) metabolism and liver status in obese subjects as well as to provide new evidence regarding the interaction of LP metabolism as a key factor in the onset and management of obesity-related diseases such as liver damage. Methods: Thirty-three subjects from the RESMENA (Reduction of Metabolic Syndrome in Navarra, NCT01087086) study were selected based on their Fatty Liver Index (FLI). Plasma lipid species (lysophosphatidilcholine: LPC, lysophosphatidilethanolamines: LPE and lysophosphatidylinositols: LPI specifically) were determined by LC-MS, while waist circumference (WC) and other non-invasive liver markers such as, FLI and BAAT scores as well as dietary records, anthropometrical measurements, body composition by DXA and other metabolic determinants were analyzed before and after a six-month hypocaloric nutritional intervention. Results: Computed Z-scores of total LP (LPC, LPE, and LPI) were significantly decreased after 6-months of following a hypocaloric diet. Specifically, LPC14:0, LPC15:0, LPC16:1, LPC18:4, LPC20:4, showed clear relationships with weight loss. Changes in FLI score, WC and BAAT score revealed associations with general changes in LPC score. Interestingly the BAAT score was statistically associated with the LPC score after adjustment for weight loss. Conclusion: The lipidomic LPC profile analysis revealed a generalized decrease in circulating lysophospholipids after weight loss. The involvement of particular LP in liver metabolism and obesity merit further attention, as some of these specific non-invasive liver markers were reduced independently of weight loss.es_ES
dc.description.sponsorshipHealth Department of the Government of Navarra [48/2009]es_ES
dc.language.isoenges_ES
dc.publisherNCBIes_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectMetabolic syndrome reductiones_ES
dc.subjectRandomized controlled-triales_ES
dc.subjectInsulin-resistancees_ES
dc.subjectDietary-treatmentes_ES
dc.subjectDiseasees_ES
dc.subjectObesityes_ES
dc.subjectFibrosises_ES
dc.subjectAssociationes_ES
dc.subjectPlasmaes_ES
dc.subjectAdultses_ES
dc.titleChanges in lysophospholipids and liver status after weight loss: the RESMENA studyes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.description.noteThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.es_ES
dc.identifier.doi10.1186/s12986-018-0288-5-
dadun.citation.publicationNameNUTRITION AND METABOLISMes_ES
dadun.citation.startingPage51es_ES
dadun.citation.volume15es_ES

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