Full metadata record
DC Field | Value | Language |
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dc.creator | Martinez-Gonzalez, M.A. (Miguel Ángel) | - |
dc.creator | Barbería-Latasa, M. (María) | - |
dc.creator | Pérez-de-Rojas, J. (Javier) | - |
dc.creator | Domínguez-Rodriguez, L.J. (Ligia Juliana) | - |
dc.creator | Gea, A. (Alfredo) | - |
dc.date.accessioned | 2022-11-04T09:23:43Z | - |
dc.date.available | 2022-11-04T09:23:43Z | - |
dc.date.issued | 2022 | - |
dc.identifier.citation | Martinez-Gonzalez, M.A. (Miguel Ángel); Barbería-Latasa, M. (María); Pérez-de-Rojas, J. (Javier); et al. "Alcohol and early mortality (before 65 years) in the ‘seguimiento Universidad de Navarra’ (SUN) cohort: does any level reduce mortality?". British Journal of Nutrition. (127), 2021, 1415 - 1425 | es_ES |
dc.identifier.issn | 0007-1145 | - |
dc.identifier.uri | https://hdl.handle.net/10171/64588 | - |
dc.description.abstract | The aim of this study was to assess the association between alcohol intake and premature mortality (younger than 65 years) and to explore the effect of potential alcohol underreporting by heavy drinkers. We followed-up 20 272 university graduates. Four categories of alcohol intake were considered (abstainer, light, moderate and heavy consumption). Repeated measurements of alcohol intake and updated information on confounders were used in time-dependent Cox models. Potential underreporting of alcohol intake by some heavy drinkers (likely misclassified as light or moderate drinkers) was explicitly addressed in an attempt to correct potential underreporting by using indirect information. During 12·3 years of median follow-up (interquartile range: 6·8–15·0), 226 participants died before their 65th birthday. A higher risk of early mortality was found for the highest category of alcohol intake (≥50 g/d) in comparison with abstention (multivariable-adjusted hazard ratio (HR) = 2·82, 95 % CI 1·38, 5·79). In analyses of alcohol as a continuous variable, the multivariable-adjusted HR was 1·17 (95 % CI 1·08, 1·26), for each 10 g/d of alcohol. This harmful linear association was present both in uncorrected models and in models corrected for potential underreporting. No significant inverse association between light or moderate alcohol intake and premature mortality was observed, even after correcting for potential misclassification. Alcohol intake exhibited a harmful linear dose–response association with premature mortality (<65 years) in this young and highly educated Mediterranean cohort. Our attempts to correct for potential misclassification did not substantially change these results. | es_ES |
dc.description.sponsorship | The SUN Project has received funding from the Spanish Government-Instituto de Salud Carlos III, and the European Regional Development Fund (FEDER) (grant numbers PI10/02658, PI10/02293, PI13/00615, PI14/01668, PI14/01798, PI14/01764, PI17/01795, PI20/00564, RD 06/0045, G03/140); the Navarra Regional Government (grant numbers 27/2011, 45/2011, 122/2014); the National Plan of Drug use prevention (Plan Nacional de Drogas, PNSD 2020/2021, grants to Maira Bes-Rastrollo and Alfredo Gea); and the European Research Council (M.A.M.G., grant number 340918). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Cambridge University Press | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Underreporting | es_ES |
dc.subject | Misclassification bias | es_ES |
dc.subject | Alcohol | es_ES |
dc.subject | FFQ | es_ES |
dc.subject | Mortality | es_ES |
dc.subject | Prospective studies | es_ES |
dc.title | Alcohol and early mortality (before 65 years) in the ‘seguimiento Universidad de Navarra’ (SUN) cohort: does any level reduce mortality? | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.description.note | This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence | es_ES |
dc.identifier.doi | 10.1017/S0007114521002397 | - |
dadun.citation.endingPage | 1425 | es_ES |
dadun.citation.number | 127 | es_ES |
dadun.citation.publicationName | British Journal of Nutrition | es_ES |
dadun.citation.startingPage | 1415 | es_ES |
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