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dc.creatorCheng, Y. (Yan)-
dc.creatorMonteiro, C. (Cátia)-
dc.creatorMatos, A. (Andreia)-
dc.creatorYou, J. (Jiaying)-
dc.creatorFraga, A. (Avelino)-
dc.creatorPereira, C. (Carina)-
dc.creatorCatalan, V. (Victoria)-
dc.creatorRodriguez, A. (Amaia)-
dc.creatorGomez-Ambrosi, J. (Javier)-
dc.creatorFrühbeck, G. (Gema)-
dc.creatorRibeiro, R. (Ricardo)-
dc.creatorHu, P. (Pingzhao)-
dc.date.accessioned2022-12-14T07:54:36Z-
dc.date.available2022-12-14T07:54:36Z-
dc.date.issued2018-
dc.identifier.citationCheng, Y. (Yan); Monteiro, C. (Cátia); Matos, A. (Andreia); et al. "Epigenome-wide DNA methylation profiling of periprostatic adipose tissue in prostate cancer patients with excess adiposity-a pilot study". Clinical epigenetics (online). 10 (54), 2018,es
dc.identifier.issn1868-7083-
dc.identifier.urihttps://hdl.handle.net/10171/64841-
dc.description.abstractBackground: Periprostatic adipose tissue (PPAT) has been recognized to associate with prostate cancer (PCa) aggressiveness and progression. Here, we sought to investigate whether excess adiposity modulates the methylome of PPAT in PCa patients. DNA methylation profiling was performed in PPAT from obese/overweight (OB/OW, BMI > 25 kg m−2 ) and normal weight (NW, BMI < 25 kg m−2 ) PCa patients. Significant differences in methylated CpGs between OB/OW and NW groups were inferred by statistical modeling. Results: Five thousand five hundred twenty-six differentially methylated CpGs were identified between OB/OW and NW PCa patients with 90.2% hypermethylated. Four hundred eighty-three of these CpGs were found to be located at both promoters and CpG islands, whereas the representing 412 genes were found to be involved in pluripotency of stem cells, fatty acid metabolism, and many other biological processes; 14 of these genes, particularly FADS1, MOGAT1, and PCYT2, with promoter hypermethylation presented with significantly decreased gene expression in matched samples. Additionally, 38 genes were correlated with antigen processing and presentation of endogenous antigen via MHC class I, which might result in fatty acid accumulation in PPAT and tumor immune evasion. Conclusions: Results showed that the whole epigenome methylation profiles of PPAT were significantly different in OB/OW compared to normal weight PCa patients. The epigenetic variation associated with excess adiposity likely resulted in altered lipid metabolism and immune dysregulation, contributing towards unfavorable PCa microenvironment, thus warranting further validation studies in larger samples.es_ES
dc.description.sponsorshipThis work was supported in part by the Natural Sciences and Engineering Research Council of Canada, Manitoba Research Health Council, University of Manitoba, and China Scholarship Council.es_ES
dc.language.isoenges_ES
dc.publisherBioMed Centrales_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectDNA methylationes_ES
dc.subjectPeriprostatic adipose tissuees_ES
dc.subjectObesityes_ES
dc.subjectProstate canceres_ES
dc.subjectMicroenvironmentes_ES
dc.titleEpigenome-wide DNA methylation profiling of periprostatic adipose tissue in prostate cancer patients with excess adiposity-a pilot studyes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.description.noteThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.es_ES
dc.identifier.doi10.1186/s13148-018-0490-3-
dadun.citation.number54es_ES
dadun.citation.publicationNameClinical epigenetics (online)es_ES
dadun.citation.volume10es_ES

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