Sacubitril-valsartan in heart failure and multimorbidity patients
Keywords: 
Sacubitril–valsartan
Elderly
Multimorbidity
Six-minute walking test
NYHA
MAGGIC score
Issue Date: 
2018
Publisher: 
Wiley Open Access
ISSN: 
2055-5822
Note: 
This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
Citation: 
Rodil-Fraile, R. (Raquel); Malafarina, V. (Vincenzo); Tiberio-López, T. (Tiberio). "Sacubitril-valsartan in heart failure and multimorbidity patients". Esc hear failure. 5 (5), 2018, 956 - 959
Abstract
Aims The poor control of symptoms in patients with advanced heart failure with reduced ejection function (HFrEF) can limit the functionality of patients. Sacubitril–valsartan, compared with enalapril, has been shown to reduce mortality and hospitalization, and nowadays, there is still little evidence about the improvement on functionality. The aim of our study is to analyse the improvement of the functional class and the 6 min walking test (6MWT) in patients with multiple pathologies and advanced heart failure. Methods and results From September 2016 to March 2018, 65 multimorbidity patients with severe symptomatic HFrEF were initiated to receive sacubitril–valsartan. Mean age was 78.6 ± 7.4 years, and 68% were male. The Charlson co-morbidity index was 8 points. Seventy-four per cent had New York Heart Association (NYHA) Functional Class IV. After the treatment, patients were able to achieve 55.68 m or more on 6MWT, and 91% presented an improvement in the NYHA functional class. Conclusions Sacubitril–valsartan relieves symptoms and improves functional class prognostic risk of patients with advanced HFrEF and co-morbidity

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