Full metadata record
DC Field | Value | Language |
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dc.creator | Valencia, K. (Karmele) | - |
dc.creator | Montuenga-Badia, L.M. (Luis M.) | - |
dc.date.accessioned | 2023-01-17T12:25:10Z | - |
dc.date.available | 2023-01-17T12:25:10Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | Valencia-Leoz, K. (Karmele); Montuenga-Badía, L. (Luis). "Exosomes in liquid biopsy: the nanometric world in the pursuit of precision oncology". Cancers. 13 (9), 2021, 2147 | es |
dc.identifier.issn | 2072-6694 | - |
dc.identifier.uri | https://hdl.handle.net/10171/64997 | - |
dc.description.abstract | Among the different components that can be analyzed in liquid biopsy, the utility of exosomes is particularly promising because of their presence in all biological fluids and their potential for multicomponent analyses. Exosomes are extracellular vesicles with an average size of similar to 100 nm in diameter with an endosomal origin. All eukaryotic cells release exosomes as part of their active physiology. In an oncologic patient, up to 10% of all the circulating exosomes are estimated to be tumor-derived exosomes. Exosome content mirrors the features of its cell of origin in terms of DNA, RNA, lipids, metabolites, and cytosolic/cell-surface proteins. Due to their multifactorial content, exosomes constitute a unique tool to capture the complexity and enormous heterogeneity of cancer in a longitudinal manner. Due to molecular features such as high nucleic acid concentrations and elevated coverage of genomic driver gene sequences, exosomes will probably become the "gold standard" liquid biopsy analyte in the near future. | - |
dc.description.sponsorship | This research was funded by SPANISH MINISTRY OF ECONOMY AND INNOVA- TION AND FONDO DE INVESTIGACIÓN SANITARIA-FONDO EUROPEO DE DESARROLLO REGIONAL (PI19/00098). | - |
dc.language.iso | en | - |
dc.rights | info:eu-repo/semantics/openAccess | - |
dc.subject | Exosomes | - |
dc.subject | Cancer | - |
dc.subject | Liquid biopsy | - |
dc.subject | Biomarkers | - |
dc.title | Exosomes in liquid biopsy: the nanometric world in the pursuit of precision oncology | - |
dc.type | info:eu-repo/semantics/review | - |
dc.description.note | This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/) | - |
dc.identifier.doi | 10.3390/cancers13092147 | - |
dadun.citation.number | 9 | - |
dadun.citation.publicationName | Cancers | - |
dadun.citation.startingPage | 2147 | - |
dadun.citation.volume | 13 | - |
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