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dc.creatorBanaszczak, M. (Marcin)-
dc.creatorMaciejewska, D. (Dominika)-
dc.creatorDrozd, A. (Arleta)-
dc.creatorRyterska, K. (Karina)-
dc.creatorJamiol-Milc, D. (Dominika)-
dc.creatorRaszeja-Wyszomirska, J. (Joanna)-
dc.creatorWunsch, E. (Eva)-
dc.creatorGonzalez-Muniesa, P. (Pedro)-
dc.creatorStachowska, E. (Ewa)-
dc.date.accessioned2023-01-30T11:00:31Z-
dc.date.available2023-01-30T11:00:31Z-
dc.date.issued2020-
dc.identifier.citationBanaszczak, M. (Marcin); Maciejewska, D. (Dominika); Drozd, A. (Arleta); et al. "5-Lipooxygenase Derivatives as Serum Biomarkers of a Successful Dietary Intervention in Patients with NonAlcoholic Fatty Liver Disease". Medicina. 56(2):58. 2020,es_ES
dc.identifier.issn1648-9144-
dc.identifier.urihttps://hdl.handle.net/10171/65194-
dc.description.abstractIt was previously shown that a bodyweight reduction among patients with nonalcoholic fatty liver (NAFLD) was connected to the lower concentration of arachidonic and linoleic acid derivatives in their blood. We hypothesized that the concentration of these lipids was correlated with the extent of their body mass reduction and, thus, liver steatosis. Methods: We analyzed 68 individuals who completed the dietary intervention. Patients were divided into two groups depending on their body mass reduction (more or less than 7%). Before and after the dietary intervention, all patients had the following measurements recorded: body mass, waist circumference, stage of steatosis, fatty liver index, liver enzymes, lipid parameters, insulin and glucose. Concentrations of lipoxins A4 (LTX A4), hydroxyeicosatetraenoic fatty acids (5(S)-HETE, 12(S)-HETE and 16(S)-HETE), hydroxyoctadecaenoic acids (9(S)-HODE and 13(S)-HODE) and 5-oxo-eicosatetraenoic acid (5-oxo-ETE) were measured in serum samples collected before and after the dietetic intervention using high-performance liquid chromatography (HPLC). Results: Patients who reduced their body mass by more than 7% revealed a significant improvement in their steatosis stage, waist circumference, fatty liver index, triglycerides and cholesterol. Conclusion: A reduction in body mass by more than 7% but not by less than 7% revealed a significant improvement in steatosis stage; waist circumference; fatty liver index; and levels of triglycerides, cholesterol, 5-oxo-ETE and LTXA-4.es_ES
dc.description.sponsorshipThe research project was supported by a grant from Narodowe Centrum Nauki (NCN), Nr N404 150539 and from the program of the Minister of Science and Higher Education under the name “Regional Initiative of Excellence” in 2019–2022, project number 002/RID/2018/19 amount of financing 12 000 000 PLNes_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.relation002/RID/2018/19es_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectDerivativeses_ES
dc.subjectNonalcoholic fatty liveres_ES
dc.subjectOxylipidses_ES
dc.subjectSteatosises_ES
dc.title5-Lipooxygenase Derivatives as Serum Biomarkers of a Successful Dietary Intervention in Patients with NonAlcoholic Fatty Liver Diseasees_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.description.noteThis article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) licensees_ES
dc.identifier.doi10.3390/medicina56020058-
dadun.citation.number2es_ES
dadun.citation.publicationNameMedicinaes_ES
dadun.citation.startingPage58es_ES
dadun.citation.volume56es_ES
dc.identifier.pmid32028646-

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