Full metadata record
DC Field | Value | Language |
---|---|---|
dc.creator | Grossi, E. (Elena) | - |
dc.creator | Raimondi, I. (Iván) | - |
dc.creator | Goñi, E. (Enrique) | - |
dc.creator | Gonzalez-Rojas, S.J. (Sandra Jovanna) | - |
dc.creator | Marchese, F.P. (Francesco P.) | - |
dc.creator | Chapaprieta, V. (Vicente) | - |
dc.creator | Martin-Subero, J.I. (Jose Ignacio) | - |
dc.creator | Guo, S. (Shuling) | - |
dc.creator | Huarte-Martínez, M. (Maite) | - |
dc.date.accessioned | 2023-02-13T13:44:12Z | - |
dc.date.available | 2023-02-13T13:44:12Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | Grossi, E. (Elena); Raimondi, I. (Iván); Goñi, E. (Enrique); et al. "A lncRNA-SWI/SNF complex crosstalk controls transcriptional activation at specific promoter regions". Nature Communications. 11, 2020, 936 | es_ES |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.issn | 32071317 | - |
dc.identifier.uri | https://hdl.handle.net/10171/65411 | - |
dc.description.abstract | LncRNAs have been shown to be direct players in chromatin regulation, but little is known about their role at active genomic loci. We investigate the role of lncRNAs in gene activation by profiling the RNA interactome of SMARCB1-containing SWI/SNF complexes in proliferating and senescent conditions. The isolation of SMARCB1-associated transcripts, together with chromatin profiling, shows prevalent association to active regions where SMARCB1 differentially binds locally transcribed RNAs. We identify SWINGN, a lncRNA interacting with SMARCB1 exclusively in proliferating conditions, exerting a pro-oncogenic role in some tumor types. SWINGN is transcribed from an enhancer and modulates the activation of GAS6 oncogene as part of a topologically organized region, as well as a larger network of pro-oncogenic genes by favoring SMARCB1 binding. Our results indicate that SWINGN influences the ability of the SWI/SNF complexes to drive epigenetic activation of specific promoters, suggesting a SWI/SNF-RNA cooperation to achieve optimal transcriptional activation. | es_ES |
dc.description.sponsorship | This work was supported by European Research Council Grant ERC-2017-COG 771425, FEDER/Ministerio de Ciencia, Innovación y Universidades -Agencia Estatal de Investigación/ BFU2017-82773-P and FP7-PEOPLE-2013-ITN. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Springer Nature | es_ES |
dc.relation | ERC-2017-COG 771425 | es_ES |
dc.relation | info:eu-repo/grantAgreement/AEI/Proyectos I+D/BFU2017-82773-P/ES/EXPLORANDO LA FUNCION DEL TRANSCRIPTOMA LARGO NO CODIFICANTE EN LA REPLICACION DE LA CROMATINA HUMANA/ | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | lncRNA-SWI/SNF | es_ES |
dc.subject | SWI/SNF complexes | es_ES |
dc.subject | RNA interactome of SMARCB1 | es_ES |
dc.title | A lncRNA-SWI/SNF complex crosstalk controls transcriptional activation at specific promoter regions | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.description.note | This article is licensed under a Creative Commons Attribution 4.0 International License | es_ES |
dc.identifier.doi | 10.1038/s41467-020-14623-3 | - |
dadun.citation.publicationName | Nature Communications | es_ES |
dadun.citation.startingPage | 936 | es_ES |
dadun.citation.volume | 11 | es_ES |
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