Full metadata record
DC Field | Value | Language |
---|---|---|
dc.creator | Londono, J. (John) | - |
dc.creator | Santos, A.M. (Ana M.) | - |
dc.creator | Rueda, J.C. (Juan C.) | - |
dc.creator | Calvo-Paramo, E. (Enrique) | - |
dc.creator | Burgos-Vargas, R. (Ruben) | - |
dc.creator | Vargas-Alarcon, G. (Giliberto) | - |
dc.creator | Martinez-Rodriguez, N. (Nancy) | - |
dc.creator | Arias-Correal, S. (Sofía) | - |
dc.creator | Muñoz, G-N. (Guisselle-Nathalia) | - |
dc.creator | Padilla, D. (Diana) | - |
dc.creator | Cuervo, F. (Francy) | - |
dc.creator | Reyes-Martinez, V. (Viviana) | - |
dc.creator | Bernal-Macías, S. (Santiago) | - |
dc.creator | Villota-Eraso, C. (Catalina) | - |
dc.creator | Avila-Portillo, L.M. (Luz M.) | - |
dc.creator | Romero, C. (Consuelo) | - |
dc.creator | Medina, J.F. (Juan Francisco) | - |
dc.date.accessioned | 2023-02-20T07:48:19Z | - |
dc.date.available | 2023-02-20T07:48:19Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | Londono, J. (John); Santos, A.M. (Ana M.); Rueda, J. (Juan); et al. "Association of ERAP2 polymorphisms in Colombian HLA-B27+ or HLA-B15+ patients with SpA and its relationship with clinical presentation: axial or peripheral predominance". RMD Open. 6(2), 2020, e001250 | es_ES |
dc.identifier.issn | 2056-5933 | - |
dc.identifier.uri | https://hdl.handle.net/10171/65504 | - |
dc.description.abstract | Objective: To determine the association between endoplasmic reticulum aminopeptidase (ERAP)1 and ERAP2 single-nucleotide polymorphisms (SNPs) and human leukocyte antigens (HLA)-B27+ or HLA-B15+ patients with spondyloarthritis (SpA). Methods: 104 patients with SpA according to Assessment of Spondyloarthritis International Society criteria were included in the study. HLA typing was performed by PCR. The polymorphisms were determined by real-time PCR on genomic DNA using customised probes for SNPs rs27044, rs17482078, rs10050860 and rs30187 in ERAP1, and rs2910686, rs2248374 and rs2549782 in ERAP2. Results: 70 of the104 patients with SpA were HLA-B27+ and 34 were HLA-B15+. The distribution of ERAP1 and ERAP2 SNPs between the HLA-B15+ and HLA-B27+ patients with SpA did not reveal differences. Likewise, no differences in the frequencies of ERAP1 SNP haplotypes and alleles HLA-B15 or HLA-B27 were found. Interestingly, however, the frequencies of three particular haplotypes formed by ERAP2 SNPs rs2549782/rs2248374/rs2910686 varied between HLA-B15+ and HLA-B27+ patients: the ERAP2 SNPs haplotype TGT was more common in HLA-B15+ patients with SpA (OR 2.943, 95/100 CI 1.264 to 6.585; P=0.009), whereas the ERAP2 SNP haplotypes TGC and CAT were more associated with HLA-B27+ patients with SpA: (OR 4.483, 95/100 CI 1.524 to 13.187; p=0.003) and (OR 9.014, 95/100 CI 1.181 to 68.807; p=0.009), respectively. Conclusion: An association was found between HLA-B15+ patients with SpA and haplotype TGT of ERAP2 SNPs. On the other hand, HLA-B27+ patients with SpA were associated with ERAP2 haplotypes TGC and CAT. These associations could be related to the clinical presentation of the disease, specifically with a peripheral or axial predominance, respectively. | es_ES |
dc.description.sponsorship | This work was supported by the University of La Sabana (Med-232-2018) and Asociación Colombiana de Reumatología (ASOREUMA) (Acta 019/2014) | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | BMJ Journals | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Ankylosing spondylitis | es_ES |
dc.subject | Autoimmune diseases | es_ES |
dc.subject | Gene polymorphism | es_ES |
dc.subject | Spondyloarthritis | es_ES |
dc.title | Association of ERAP2 polymorphisms in Colombian HLA-B27+ or HLA-B15+ patients with SpA and its relationship with clinical presentation: axial or peripheral predominance | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.description.note | This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license. | es_ES |
dc.identifier.doi | 10.1136/rmdopen-2020-001250 | - |
dadun.citation.number | 2 | es_ES |
dadun.citation.publicationName | RMD Open | es_ES |
dadun.citation.startingPage | e001250 | es_ES |
dadun.citation.volume | 6 | es_ES |
dc.identifier.pmid | 32917832 | - |
Files in This Item:
Statistics and impact
Items in Dadun are protected by copyright, with all rights reserved, unless otherwise indicated.