Association of a genetic risk score with BMI along the life-cycle: evidence from several US cohorts

Sanz-de-Galdeano, A. (Anna); Terskaya, A. (Anastasia); Upegui, A. (Angie)

Authors:

Sanz-de-Galdeano, A. (Anna)

Terskaya, A. (Anastasia)

Upegui, A. (Angie)

Keywords:

BMI
US cohorts
Obesity
Genetics
Phenotypes

Issue Date:

2020

Publisher:

PLOS

Project:

info:eu-repo/grantAgreement/AEI/Proyectos I+D/ECO2017-87069-P/ES/MICROECONOMIA APLICADA Y ECONOMIA FINANCIERA EMPIRICA

ISSN:

1932-6203

Note:

This is an open access article distributed under the terms of the Creative Commons Attribution License

Citation:

Sanz-de-Galdeano, A. (Anna); Terskaya, A. (Anastasia); Upegui, A. (Angie). "Association of a genetic risk score with BMI along the life-cycle: Evidence from several US cohorts". PLOS ONE. 15 (9), 2020, e0239067

Abstract

We use data from the National Longitudinal Study of Adolescent to Adult Health and from the Health and Retirement Study to explore how the effect of individuals’ genetic predisposition to higher BMI —measured by BMI polygenic scores— changes over the life-cycle for several cohorts. We find that the effect of BMI polygenic scores on BMI increases significantly as teenagers transition into adulthood (using the Add Health cohort, born 1974-83). However, this is not the case for individuals aged 55+ who were born in earlier HRS cohorts (1931-53), whose life-cycle pattern of genetic influence on BMI is remarkably stable as they move into old-age.

URI:

https://hdl.handle.net/10171/65508

DOI:

10.1371/journal.pone.0239067

Appears in Collections:

DA - Economía - Artículo de revista

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