Genome-wide association study identifies the GLDC/IL33 locus associated with survival of osteosarcoma patients

Koster, R. (Roelof); Panagiotou, O.A. (Orestis A.); Wheeler, W. (William); Karlins, E. (Eric); Gastier-Foster, J.M. (Julie M.); Caminada-de-Toledo, S.R. (Silvia Regina); Petrilli, A.S. (Antonio S.); Flanagan, A.M. (Adrienne M.); Tirabosco, R. (Roberto); Andrulis, I.L. (Irene L.); Wunder, J.S. (Jay S.); Gokgoz, N. (Nalan); Patiño-García, A. (Ana); Lecanda, F. (Fernando); Serra, M. (Massimo); Hattinger, C. (Claudia); Picci, P. (Piero); Scotlandi, K. (Katia); Thomas, D.M. (David M.); Ballinger, M.L. (Mandy L.); Gorlick, R.G. (Richard G.); Barkauskas, D.A. (Donald A.); Spector, L. (Logan); Tucker, M. (Margaret); Hicks, B. (Belynda); Yeager, M. (Meredith); Hoover, R.N. (Robert N.); Wacholder, S. (Sholom); Chanock, S.J. (Stephen J.); Savage, S.A. (Sharon A.); Mirabello, L. (Lisa)

Keywords:

Osteosarcoma
Overall survival
Genome-wide association study
Osteosarcoma-specific survival

Issue Date:

2018

Publisher:

John Wiley & Sons, Ltd

Project:

info:eu-repo/grantAgreement/MINECO/Proyectos de investigación en salud (AE en Salud)/PI13/01476/ES/INMUNOTERAPIA CON CÉLULAS DENDRÍTICAS CONTRA TUMORES SÓLIDOS PEDIÁTRICOS
1U24CA114766-01 - - Human Specimen Banking in NCI-Supported Cancer Clinical

ISSN:

0020-7136

Citation:

Koster, R. (Roelof); Panagiotou, O.A. (Orestis A.); Wheeler, W. (William); et al. "Genome-wide association study identifies the GLDC/IL33 locus associated with survival of osteosarcoma patients". Cancer research. 142 (8), 2018, 1594 - 1601

Abstract

Survival rates for osteosarcoma, the most common primary bone cancer, have changed little over the past three decades and are particularly low for patients with metastatic disease. We conducted a multi-institutional genome-wide association study (GWAS) to identify germline genetic variants associated with overall survival in 632 patients with osteosarcoma, including 523 patients of European ancestry and 109 from Brazil. We conducted a time-to-event analysis and estimated hazard ratios (HR) and 95% confidence intervals (CI) using Cox proportional hazards models, with and without adjustment for metastatic disease.

URI:

https://hdl.handle.net/10171/65525

DOI:

10.1002/ijc.31195

Appears in Collections:

DA - CUN - Pediatría - Artículos de revista

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