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dc.creatorChristensen, P. (Pia)-
dc.creatorMeinert-Larsen, T. (Thomas)-
dc.creatorWesterterp-Plantenga, M. (Margriet)-
dc.creatorMacDonald, I. (Ian)-
dc.creatorMartinez, J.A. (José Alfredo)-
dc.creatorHandjiev, S. (Svetoslav)-
dc.creatorPoppitt, S.D. (Sally D.)-
dc.creatorHansen, S. (Sylvia)-
dc.creatorRitz, C. (Christian)-
dc.creatorAstrup, A. (Arne)-
dc.creatorPastor-Sanz, L. (Laura)-
dc.creatorSando-Pedersen, F. (Finn)-
dc.creatorPietiläinen, K.H. (Kirsi H.)-
dc.creatorSundvall, J. (Jouko)-
dc.creatorDrummen, M. (Mathijs)-
dc.creatorTaylor, M. (Moira)-
dc.creatorNavas-Carretero, S. (Santiago)-
dc.creatorHandjieva-Darlenska, T. (Teodora)-
dc.creatorBrodie, S. (Shannon)-
dc.creatorSilvestre, M.P. (Marta P.)-
dc.creatorHuttunen-Lenz, M. (Maija)-
dc.creatorBrand-Miller, J. (Jennie)-
dc.creatorFogelholm, M. (Mikael)-
dc.creatorRaben, A. (Anne)-
dc.date.accessioned2023-02-27T09:38:40Z-
dc.date.available2023-02-27T09:38:40Z-
dc.date.issued2018-
dc.identifier.citationChristensen, P. (Pia); Meinert-Larsen, T. (Thomas); Westerterp-Plantenga, M. (Margriet); et al. "Men and women respond differently to rapid weight loss: Metabolic outcomes of a multi-centre intervention study after a low-energy diet in 2500 overweight, individuals with pre-diabetes (PREVIEW)". Diabetes obesity and metabolism. 20 (12), 2018, 2840 - 2851es_ES
dc.identifier.issn1462-8902-
dc.identifier.urihttps://hdl.handle.net/10171/65565-
dc.description.abstractAims: The PREVIEW lifestyle intervention study (ClinicalTrials.gov Identifier: NCT01777893) is, to date, the largest, multinational study concerning prevention of type-2 diabetes. We hypothesized that the initial, fixed low-energy diet (LED) would induce different metabolic outcomes in men vs women. Materials and methods: All participants followed a LED (3.4 MJ/810 kcal/daily) for 8 weeks (Cambridge Weight Plan). Participants were recruited from 8 sites in Europe, Australia and New Zealand. Those eligible for inclusion were overweight (BMI ≥ 25 kg/m2 ) individuals with pre-diabetes according to ADA-criteria. Outcomes of interest included changes in insulin resistance, fat mass (FM), fat-free mass (FFM) and metabolic syndrome Z-score. Results: In total, 2224 individuals (1504 women, 720 men) attended the baseline visit and 2020 (90.8%) completed the follow-up visit. Following the LED, weight loss was 16% greater in men than in women (11.8% vs 10.3%, respectively) but improvements in insulin resistance were similar. HOMA-IR decreased by 1.50 ± 0.15 in men and by 1.35 ± 0.15 in women (ns). After adjusting for differences in weight loss, men had larger reductions in metabolic syndrome Z-score, C-peptide, FM and heart rate, while women had larger reductions in HDL cholesterol, FFM, hip circumference and pulse pressure. Following the LED, 35% of participants of both genders had reverted to normo-glycaemia. Conclusions: An 8-week LED induced different effects in women than in men. These findings are clinically important and suggest gender-specific changes after weight loss. It is important to investigate whether the greater decreases in FFM, hip circumference and HDL cholesterol in women after rapid weight loss compromise weight loss maintenance and future cardiovascular health.es_ES
dc.description.sponsorshipFunding information Funding was received from the EU 7th Framework Programme (FP7/2007-2013) under grant agreement no. 312057, The National Health and Medical Research Council - EU Collaborative Grant, AUS, The NZ Health Research Council (14/191) and the UoA Faculty Research Development Fund. The Cambridge Weight Plan, UK kindly donated all products for the 8-week Low-Energy Diet period.es_ES
dc.language.isoenges_ES
dc.publisherWileyes_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectDietary interventiones_ES
dc.subjectObesityes_ES
dc.subjectPreventiones_ES
dc.subjectWeight losses_ES
dc.subjectPre-diabeteses_ES
dc.titleMen and women respond differently to rapid weight loss: Metabolic outcomes of a multi-centre intervention study after a low-energy diet in 2500 overweight, individuals with pre-diabetes (PREVIEW)es_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.description.noteThis is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.es_ES
dc.identifier.doi10.1111/dom.13466-
dadun.citation.endingPage2851es_ES
dadun.citation.number12es_ES
dadun.citation.publicationNameDiabetes obesity and metabolismes_ES
dadun.citation.startingPage2840es_ES
dadun.citation.volume20es_ES
dc.identifier.pmid30088336-

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