Full metadata record
DC FieldValueLanguage
dc.creatorDi-Caudo, C. (Carla)-
dc.creatorMartinez-Valbuena, I. (Iván)-
dc.creatorCarril-Mundiñano, I. (Iñaki)-
dc.creatorGennetier, A. (Aurelie)-
dc.creatorHernandez, M. (María)-
dc.creatorCarmona-Abellán, M.M. (María del Mar)-
dc.creatorMarcilla-Garcia, I. (Irene)-
dc.creatorKremer, E.J. (Eric J.)-
dc.creatorLuquin, M.R. (María Rosario)-
dc.date.accessioned2023-02-28T08:17:53Z-
dc.date.available2023-02-28T08:17:53Z-
dc.date.issued2020-
dc.identifier.citationDi-Caudo, C. (Carla); Martinez-Valbuena, I. (Iván); Carril-Mundiñano, I. (Iñaki); et al. "CAV-2-Mediated GFP and LRRK2G2019S Expression in the Macaca fascicularis Brain". Frontiers in Molecular Neuroscience. 13 (49), 2020,es_ES
dc.identifier.issn1662-5099-
dc.identifier.urihttps://hdl.handle.net/10171/65578-
dc.description.abstractParkinson’s disease is characterized by motor and nonmotor symptoms that gradually appear as a consequence of the selective loss of dopaminergic neurons in the substantia nigra pars compacta. Currently, no treatment can slow Parkinson’s disease progression. Inasmuch, there is a need to develop animal models that can be used to understand the pathophysiological mechanisms underlying dopaminergic neuron death. The initial goal of this study was to determine if canine adenovirus type 2 (CAV-2) vectors are effective gene transfer tools in the monkey brain. A second objective was to explore the possibility of developing a large nonhuman primate that expresses one of the most common genetic mutations causing Parkinson’s disease. Our studies demonstrate the neuronal tropism, retrograde transport, biodistribution, and efficacy of CAV-2 vectors expressing GFP and leucine-rich repeat kinase 2 (LRRK2G2019S) in the Macaca fascicularis brain. Our data also suggest that following optimization CAV-2-mediated LRRK2G2019S expression could help us model the neurodegenerative processes of this genetic subtype of Parkinson’s disease in monkeys.es_ES
dc.description.sponsorshipWe thank the European Commission Seventh Framework Programme (FP7) CP (BrainCAV: FP7-HEALTH-2007-222992, EK and RL) and BrainVectors (FP7-HEALTH-2012-286071, EK); Government of Navarra (CTP-09-P8, RL); Foundation for Applied Medical Research (RL); Universidad de Navarra (RL); France Parkinson’s (EK), Association pour la recherche sur la sclérose latérale amyotrophique (EK); Université de Montpellier (EK), La Fondation pour la Recherche Médicale (EK); and the LabEx EpiGenMed (EK). IM-V was supported by ‘‘Asociación de Amigos de la Universidad de Navarra.’’es_ES
dc.language.isoenges_ES
dc.relationinfo:eu-repo/grantAgreement/EC/FP7/222992/EUes_ES
dc.relationinfo:eu-repo/grantAgreement/EC/FP7/286071/EUes_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectM. fascicularises_ES
dc.subjectCAV-2es_ES
dc.subjectViral vectorses_ES
dc.subjectGFPes_ES
dc.subjectLRRK2es_ES
dc.subjectParkinson’s diseasees_ES
dc.subjectNonhuman primatees_ES
dc.subjectCNSes_ES
dc.titleCAV-2-Mediated GFP and LRRK2G2019S Expression in the Macaca fascicularis Braines_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.description.noteThis is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.es_ES
dc.identifier.doi10.3389/fnmol.2020.00049-
dadun.citation.number49es_ES
dadun.citation.publicationNameFrontiers in Molecular Neurosciencees_ES
dadun.citation.volume13es_ES

Files in This Item:
Thumbnail
File
fnmol-13-00049.pdf
Description
Size
7.14 MB
Format
Adobe PDF


Statistics and impact
0 citas en
0 citas en

Items in Dadun are protected by copyright, with all rights reserved, unless otherwise indicated.