Full metadata record
DC Field | Value | Language |
---|---|---|
dc.creator | Figueroa, R. (Rocío) | - |
dc.creator | Alfonso, A. (A.) | - |
dc.creator | Lopez-Picazo, J.M. (José M.) | - |
dc.creator | Gil-Bazo, I. (Ignacio) | - |
dc.creator | Garcia-Mouriz, A. (Alberto) | - |
dc.creator | Hermida, J. (José) | - |
dc.creator | Paramo, J.A. (José Antonio) | - |
dc.creator | Lecumberri, R. (Ramón) | - |
dc.date.accessioned | 2023-03-01T12:24:39Z | - |
dc.date.available | 2023-03-01T12:24:39Z | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | Figueroa, R. (Rocío); Alfonso, A. (A.); Lopez-Picazo, J.M. (José M.); et al. "Insights into venous thromboembolism prevention in hospitalized cancer patients: Lessons from a prospective study". Plos one. 13 (8), 2018, e0200220 | es_ES |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | https://hdl.handle.net/10171/65594 | - |
dc.description.abstract | Hospitalized cancer patients are at high risk of venous thromboembolism (VTE). Despite current recommendations in clinical guidelines, thromboprophylaxis with low molecular weight heparin (LMWH) is underused. We performed an observational prospective study to analyse factors influencing prophylaxis use, VTE events and mortality in cancer-hospitalized patients. 1072 consecutive adult cancer patients were included in an University Hospital from April 2014 to February 2017, and followed-up for 30 days after discharge. The rate of LMWH prophylaxis was 67.6% (95% confidence interval [CI] 64.7% to 70.4%), with a 2.8% rate of VTE events (95% CI 1.9% to 3.9%) and 3.5% rate of major bleeding events (95% CI 2.5% to 4.8%). 80% of VTE events occurred despite appropriate thromboprophylaxis. Overall, 30-day mortality rate was 13.2% (95% CI 11.2% to 15.3%). Active chemotherapy treatment, hospital stay 4 days, and metastatic disease were associated with a higher use of LMWH. On the contrary, patients with hematologic malignancies, anemia or thrombocytopenia were less prone to receive thromboprophylaxis. The main reasons for not prescribing LMWH prophylaxis were thrombocytopenia (23.9%) and active/recent bleeding (21.8%). The PRETEMED score, used for VTE risk stratification, correlated with 30-day mortality. There is room for improvement in thromboprophylaxis use among hospitalized-cancer patients, especially among those with hematologic malignancies. A relevant number of VTE events occurred despite prophylaxis with LMWH. Therefore, identification of risk factors for thromboprophylaxis failure is needed. | es_ES |
dc.description.sponsorship | This work has been partially funded by a biomedical research grant by Laboratorios Farmace´uticos ROVI and an aid for research projects from the Instituto de Salud Carlos III and the FEDER (PI13/01029) (RL). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Public Library of Science | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/Proyectos de investigación en salud (AE en Salud)/PI13%2F01029/ES/Impacto de un sistema de alerta electrónica 2.0 para la prevención del tromboembolismo venoso en pacientes oncohematológicos hospitalizados | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Hospitalized cancer patients | es_ES |
dc.subject | Venous thromboembolism (VTE) | es_ES |
dc.subject | Low molecular weight heparin (LMWH) | es_ES |
dc.title | Insights into venous thromboembolism prevention in hospitalized cancer patients: Lessons from a prospective study | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.description.note | This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited | es_ES |
dc.identifier.doi | 10.1371/journal.pone.0200220 | - |
dadun.citation.number | 8 | es_ES |
dadun.citation.publicationName | Plos one | es_ES |
dadun.citation.startingPage | e0200220 | es_ES |
dadun.citation.volume | 13 | es_ES |
Files in This Item:
Statistics and impact
Items in Dadun are protected by copyright, with all rights reserved, unless otherwise indicated.