Interferon gamma, an important marker of response to immune checkpoint blockade in non-small cell lung cancer and melanoma patients

Karachaliou, N. (Niki); Gonzalez-Cao, M. (María); Crespo, G. (Guillermo); Drozdowskyj, A. (Ana); Aldeguer, E. (Erika); Gimenez-Capitan, A. (Ana); Teixidó, C. (Cristina); Molina-Vila, M.A. (Miguel Angel); Viteri, S. (S.); Llanos-Gil, M. (Maria) de los; Martin-Algarra, S. (Salvador); Perez-Ruiz, E. (Elisabeth); Marquez-Rodas, I. (Iván); Rodríguez-Abreu, D. (Delvys); Blanco, R. (Remedios); Puertolas, T. (Teresa); Royo, M.A. (María Ángeles); Rosell, R. (Rafael)

Keywords:

Immunotherapy
Interferon-gamma
PD-1
PD-L1
Lung cancer
Melanoma

Issue Date:

2018

Publisher:

SAGE Publications

ISSN:

1758-8340

Note:

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

Citation:

Karachaliou, N. (Niki); Gonzalez-Cao, M. (María); Crespo, G. (Guillermo); et al. "Interferon gamma, an important marker of response to immune checkpoint blockade in non-small cell lung cancer and melanoma patients". Therapeutic advances in medical oncology. 10, 2018, 1 - 23

Abstract

Background: Programmed death-ligand 1 (PD-L1) may be induced by oncogenic signals or can be upregulated via interferon gamma (IFN-y). We have explored whether the expression of IFNG, the gene encoding IFN-y, is associated with clinical response to the immune checkpoint blockade in non-small cell lung cancer (NSCLC) and melanoma patients. The role of inflammation-associated transcription factors STAT3, IKBKE, STAT1 and other associated genes has also been examined.

URI:

https://hdl.handle.net/10171/65643

DOI:

10.1177/1758834017749748

Appears in Collections:

DA - CUN - Oncología médica - Artículos de revista

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