Reverse myocardial remodeling following valve replacement in patients with aortic stenosis

Treibel, T.A. (Thomas A.); Kozor, R. (Rebecca); Schofield, R.S. (Rebecca S.); Benedetti, G. (Giulia); Fontana, M. (Marianna); Bhuva, A.N. (Anish N.); Sheikh, A. (Amir); López, B. (Begoña); Gonzalez, A. (Arantxa); Manisty, C. (Charlotte); Lloyd, G. (Guy); Kellman, P. (Peter); Diez, J. (Javier); Moon, J.C. (James C.)

Keywords:

Left ventricular (LV)
Hypertrophy
Interstitial fibrosis
Extracellular matrix expansion

Issue Date:

2018

Publisher:

Elsevier BV

Project:

602904 - FIBRO-TARGETS - Targeting cardiac fibrosis for heart failure treatment

ISSN:

0735-1097

Note:

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

Citation:

Treibel, T.A. (Thomas A.); Kozor, R. (Rebecca); Schofield, R.S. (Rebecca S.); et al. "Reverse myocardial remodeling following valve replacement in patients with aortic stenosis". Journal of the american college of cardiology. 71 (8), 2018, 869 - 871

Abstract

Background Left ventricular (LV) hypertrophy, a key process in human cardiac disease, results from cellular (hypertrophy) and extracellular matrix expansion (interstitial fibrosis). Objectives This study sought to investigate whether human myocardial interstitial fibrosis in aortic stenosis (AS) is plastic and can regress.

URI:

https://hdl.handle.net/10171/65657

DOI:

10.1016/j.jacc.2017.12.035

Appears in Collections:

DA - CIMA - Enfermedades cardiovasculares - Remodelado miocárdico - Artículos de Revista

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