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dc.creatorCalvo-Manuel, F.Á. (Felipe Ángel)-
dc.creatorSerrano-Andreu, J. (Javier)-
dc.creatorSolé, C. (Claudio)-
dc.creatorCambeiro, M. (Mauricio)-
dc.creatorPalma, J. (Jacobo)-
dc.creatorAristu-Mendioroz, J.J. (José Javier)-
dc.creatorGarcía-Sabrido, J.L. (José Luis)-
dc.creatorCuesta, M.A. (Miguel Ángel)-
dc.creatorValle, E. (Emilio) del-
dc.creatorLapuente, F. (Fernando)-
dc.creatorMiñana-López, B. (Bernardino)-
dc.creatorMorcillo, M.A. (Miguel Ángel)-
dc.creatorAsencio, J.M. (José Manuel)-
dc.creatorPascau, J. (Javier)-
dc.date.accessioned2023-03-20T12:11:09Z-
dc.date.available2023-03-20T12:11:09Z-
dc.date.issued2022-
dc.identifier.citationCalvo-Manuel, F.Á. (Felipe Ángel); Serrano, J. (Javier); Solé, C. (Claudio); et al. "Clinical feasibility of combining intraoperative electron radiation therapy with minimally invasive surgery: a potential for electron-FLASH clinical development". Clinical and Translational Oncology. (25), 2022, 429 - 439es_ES
dc.identifier.issn1699-3055-
dc.identifier.urihttps://hdl.handle.net/10171/65745-
dc.description.abstractBackground Local cancer therapy by combining real-time surgical exploration and resection with delivery of a single dose of high-energy electron irradiation entails a very precise and efective local therapeutic approach. Integrating the benefts from minimally invasive surgical techniques with the very precise delivery of intraoperative electron irradiation results in an efcient combined modality therapy. Methods Patients with locally advanced disease, who are candidates for laparoscopic and/or thoracoscopic surgery, received an integrated multimodal management. Preoperative treatment included induction chemotherapy and/or chemoradiation, followed by laparoscopic surgery and intraoperative electron radiation therapy. Results In a period of 5 consecutive years, 125 rectal cancer patients were treated, of which 35% underwent a laparoscopic approach. We found no diferences in cancer outcomes and tolerance between the open and laparoscopic groups. Two esophageal cancer patients were treated with IOeRT during thoracoscopic resection, with the resection specimens showing intense downstaging efects. Two oligo-recurrent prostatic cancer patients (isolated nodal progression) had a robotic-assisted surgical resection and post-lymphadenectomy electron boost on the vascular and lateral pelvic wall. Conclusions Minimally invasive and robotic-assisted surgery is feasible to combine with intraoperative electron radiation therapy and ofers a new model explored with electron-FLASH beams.es_ES
dc.description.sponsorshipThis research was funded in part by grants from: Instituto de Salud Carlos III, Asociación Española Contra el Cáncer, ERAPERMED PerPlanRT, AC20/00103, AC20/00102, 2020–110-1), Ministry of Science, Innovation and Education PID 2019-104558RB-100.es_ES
dc.language.isoenges_ES
dc.publisherSpringeres_ES
dc.relationinfo:eu-repo/grantAgreement/ISCIII/Proyectos de programación conjunta internacional/AC20/001027ES/TRATAMIENTO PERSONALIZADO EN RADIOTERAPIA MEDIANTE MODELADO INTEGRADO DE NUEVAS RESTRICCIONES Y EFECTOS DOSIMETRICOS LOCALES/es_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectIntraoperative radiation therapyes_ES
dc.subjectElectron beamses_ES
dc.subjectLaparoscopic surgeryes_ES
dc.subjectRobotic surgeryes_ES
dc.subjectCancer surgeryes_ES
dc.subjectFLASHes_ES
dc.titleClinical feasibility of combining intraoperative electron radiation therapy with minimally invasive surgery: a potential for electron-FLASH clinical developmentes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.description.noteThis article is licensed under a Creative Commons Attribution 4.0 International Licensees_ES
dc.identifier.doi10.1007/s12094-022-02955-z-
dadun.citation.endingPage439es_ES
dadun.citation.number25es_ES
dadun.citation.publicationNameClinical and Translational Oncologyes_ES
dadun.citation.startingPage429es_ES

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