The exposure to uteroplacental insufficiency is associated with activation of unfolded protein response in postnatal life

Deodati, A. (Annalisa); Argemí, J. (Josepmaria); Germani, D. (Daniela); Puglianiello, A. (Antonella); Alisi, A. (Anna); Stefanis, C. (Cristiano); Ferrero, R. (Roberto); Nobili, V. (Valerio); Aragón-Amonárriz, T. (Tomás); Cianfarani, S. (Stefano)

Keywords:

Chronic diseases
Adult life
Unfolded protein response (UPR)

Issue Date:

2018

Publisher:

Plos One

ISSN:

1932-6203

Note:

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Citation:

Deodati, A. (Annalisa); Argemí, J. (Josepmaria); Germani, D. (Daniela); et al. "The exposure to uteroplacental insufficiency is associated with activation of unfolded protein response in postnatal life". Plos one. 13 (6), 2018, e0198490

Abstract

Early life events are associated with the susceptibility to chronic diseases in adult life. Perturbations of endoplasmic reticulum (ER) homeostasis activate the unfolded protein response (UPR), which contributes to the development of metabolic alterations. Our aim was to evaluate liver UPR in an animal model of intrauterine growth restriction (IUGR).

URI:

https://hdl.handle.net/10171/65811

DOI:

10.1371/journal.pone.0198490

Appears in Collections:

DA - CIMA - Hepatología - Hepatología del cáncer - Artículos de revista

Files in This Item: