Materias Investigacion::Ciencias de la vida Refractory facial Darier's Photodynamic therapy
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Morelló-Vicente, A. (Ana); Antoñanzas, J. (Javier); Estenaga, Á. (Ángela); et al. "Refractory facial Darier's disease treated with daylight photodynamic therapy". Journal of the German Society of Dermatology. 20 (12), 2022, 1633 - 1635
Darier’s disease (DD) is an infrequent autosomal dominant skin disorder caused by a mutation of the ATP2A2 gene on chromosome 12 . Mutations in this gene result in abnorma-lities in keratinocyte cell-cell adhesion producing an alterati-on of the keratinization of the skin, which clinically presents with dyskeratotic papules mostly affecting seborrheic and in-tertriginous areas. Palmoplantar and nail involvement is often present [1–3]. As a wide range of treatments have been propo-sed for this skin disorder with different results, the manage-ment of this disease is still a challenge for the dermatologist.