Technological advances in ocular trabecular meshwork in vitro models for glaucoma research
Keywords: 
Aqueous humor outflow
Glaucoma
Scaffolds
Tissue‐engineering
Trabecular meshwork
Issue Date: 
2022
Publisher: 
Wiley
Project: 
info:eu-repo/grantAgreement/ISCIII/Proyectos de investigación en salud/PI18‐01782/ES/IDENTIFICACION DE NUEVAS DIANAS PARA EL TRATAMIENTO DEL GLAUCOMA BASADOS EN LOS CAMBIOS BIOFISICOS Y PRESION INTRAOCULAR SOBRE LAS HTMC EN UN MODELO 3D DE MALLA TRABECULAR.
ISSN: 
1097-0290
Note: 
This is an open access article under the terms of the Creative Commons Attribution License
Citation: 
Bikuna-Izagirre, M. (María); Aldazabal, J. (Javier); Extramiana, L. (Leire); et al. "Technological advances in ocular trabecular meshwork in vitro models for glaucoma research". Biotechnology & Bioengineering. 119 (10), 2022, 2698 - 2714
Abstract
Glaucoma is the leading cause of irreversible blindness worldwide and ischaracterized by the progressive degeneration of the optic nerve. Intraocularpressure (IOP), which is considered to be the main risk factor for glaucomadevelopment, builds up in response to the resistance (resistance to what?) providedby the trabecular meshwork (TM) to aqueous humor (AH) outflow. Although theTMand its relationship to AH outflow have remained at the forefront of scientificinterest, researchers remain uncertain regarding which mechanisms drive thedeterioration of the TM. Current tissue‐engineering fabrication techniques havecome up with promising approaches to successfully recreate the TM. Nonetheless,more accurate models are needed to understand the factors that make glaucomaarise. In this review, we provide a chronological evaluation of the technologicalmilestones that have taken place in the field of glaucoma research, and we conduct acomprehensive comparison of available TM fabrication technologies. Additionally,we also discuss AH perfusion platforms, since they are essential for the validation ofthese scaffolds, as well as pressure–outflow relationship studies and the discovery ofnew IOP‐reduction therapies.

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