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dc.creatorDivo, M. (Miguel)-
dc.creatorMarín-Oto, M. (Marta)-
dc.creatorCasanova-Macario, C. (Ciro)-
dc.creatorCabrera-Lopez, C. (Carlos)-
dc.creatorde-Torres, J.P. (Juan P.)-
dc.creatorMarin-Trigo, J.M. (Jose Maria)-
dc.creatorHersh, C.P. (Craig P.)-
dc.creatorEzponda, A. (Ana)-
dc.creatorMaguire, C. (Cherie)-
dc.creatorPinto-Plata, V. (Víctor)-
dc.creatorPolverino, F. (Francesca)-
dc.creatorRoss, J.C. (James C.)-
dc.creatorDeMeo, D. (Dawn)-
dc.creatorBastarrika, G. (Gorka)-
dc.creatorSilverman, E. (Edwin)-
dc.creatorCelli, B.R. (Bartolomé R.)-
dc.date.accessioned2023-05-15T10:46:40Z-
dc.date.available2023-05-15T10:46:40Z-
dc.date.issued2020-
dc.identifier.citationDivo, M. (Miguel); Marín-Oto, M. (Marta); Casanova-Macario, C. (Ciro); et al. "Somatotypes trajectories during adulthood and their association with COPD phenotypes". EPJ open research. 6 (3), 2020, 00122-2020es_ES
dc.identifier.issn2312-0541-
dc.identifier.urihttps://hdl.handle.net/10171/66235-
dc.description.abstractRationale: Chronic obstructive pulmonary disease (COPD) comprises distinct phenotypes, all characterised by airflow limitation. Objectives: We hypothesised that somatotype changes – as a surrogate of adiposity – from early adulthood follow different trajectories to reach distinct phenotypes. Methods: Using the validated Stunkard’s Pictogram, 356 COPD patients chose the somatotype that best reflects their current body build and those at ages 18, 30, 40 and 50 years. An unbiased group-based trajectory modelling was used to determine somatotype trajectories. We then compared the current COPD-related clinical and phenotypic characteristics of subjects belonging to each trajectory. Measurements and main results: At 18 years of age, 88% of the participants described having a lean or medium somatotype (estimated body mass index (BMI) between 19 and 23 kg·m−2 ) while the other 12% a heavier somatotype (estimated BMI between 25 and 27 kg·m−2 ). From age 18 onwards, five distinct trajectories were observed. Four of them demonstrating a continuous increase in adiposity throughout adulthood with the exception of one, where the initial increase was followed by loss of adiposity after age 40. Patients with this trajectory were primarily females with low BMI and DLCO (diffusing capacity of the lung for carbon monoxide). A persistently lean trajectory was seen in 14% of the cohort. This group had significantly lower forced expiratory volume in 1 s (FEV1), DLCO, more emphysema and a worse BODE (BMI, airflow obstruction, dyspnoea and exercise capacity) score thus resembling the multiple organ loss of tissue (MOLT) phenotype. Conclusions: COPD patients have distinct somatotype trajectories throughout adulthood. Those with the MOLT phenotype maintain a lean trajectory throughout life. Smoking subjects with this lean phenotype in early adulthood deserve particular attention as they seem to develop more severe COPD.es_ES
dc.description.sponsorshipThe COPDGene cohort (NCT00608764) is funded by National Institutes of Health (NIH) grants U01HL089856 and U01HL089897 and is also supported by the COPD Foundation through contributions made to an Industry Advisory Committee comprised of AstraZeneca, Boehringer Ingelheim, GlaxoSmithKline, Novartis, and Sunovion. Funding information for this article has been deposited with the Crossref Funder Registryes_ES
dc.language.isoenges_ES
dc.publisherEuropean Respiratory Societyes_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectChronic obstructive pulmonary disease (COPD)es_ES
dc.subjectAirflow limitationes_ES
dc.subjectAdiposityes_ES
dc.subjectSomatotypees_ES
dc.titleSomatotypes trajectories during adulthood and their association with COPD phenotypeses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.description.noteThis article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0.es_ES
dc.identifier.doi10.1183/23120541.00122-2020-
dadun.citation.number3es_ES
dadun.citation.publicationNameEPJ open researches_ES
dadun.citation.startingPage00122-2020es_ES
dadun.citation.volume6es_ES
dc.identifier.pmidPMC7487345-

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