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dc.creatorMoreno-Ajona, D. (David)-
dc.creatorIrimia, P. (Pablo)-
dc.creatorRodriguez, J.A. (José Antonio)-
dc.creatorGarcia-Velloso, M. J. (María José)-
dc.creatorLópez-Fidalgo, J. (Jesús)-
dc.creatorFernandez-Alonso, L. (Leopoldo)-
dc.creatorGrochowitz, L. (Lukasz)-
dc.creatorMuñoz, R. (Roberto)-
dc.creatorDominguez, P.D. (Pablo Daniel)-
dc.creatorGállego-Culleré, J. (Jaime)-
dc.creatorMartinez-Vila, E. (Eduardo)-
dc.identifier.citationMoreno-Ajona, D. (David); Irimia, P. (Pablo); Rodriguez, J.A. (José Antonio); et al. "Elevated circulating metalloproteinase 7 predicts recurrent cardiovascular events in patients with carotid stenosis: a prospective cohort study". BMC Cardiovascular Disorders. 20 (93), 2020,es_ES
dc.description.abstractBackground: Major adverse cardiovascular events are the main cause of morbidity and mortality over the long term in patients undergoing carotid endarterectomy. There are few reports assessing the prognostic value of markers of inflammation in relation to the risk of cardiovascular disease after carotid endarterectomy. Here, we aimed to determine whether matrix metalloproteinases (MMP-1, MMP-2, MMP-7, MMP-9 and MMP-10), tissue inhibitor of MMPs (TIMP-1) and in vivo inflammation studied by 18F-FDG-PET/CT predict recurrent cardiovascular events in patients with carotid stenosis who underwent endarterectomy. Methods: This prospective cohort study was carried out on 31 consecutive patients with symptomatic (23/31) or asymptomatic (8/31) severe (> 70%) carotid stenosis who were scheduled for carotid endarterectomy between July 2013 and March 2016. In addition, 26 healthy controls were included in the study. Plasma and serum samples were collected 2 days prior to surgery and tested for MMP-1, MMP-2, MMP-7, MMP-9, MMP-10, TIMP-1, high-density lipoprotein, low-density lipoprotein, high-sensitivity C-reactive protein and erythrocyte sedimentation rate. 18F-FDGPET/CT focusing on several territories’ vascular wall metabolism was performed on 29 of the patients because of no presurgical availability in 2 symptomatic patients. Histological and immunohistochemical studies were performed with antibodies targeting MMP-10, MMP-9, TIMP-1 and CD68. Results: The patients with carotid stenosis had significantly more circulating MMP-1, MMP-7 and MMP-10 than the healthy controls. Intraplaque TIMP-1 was correlated with its plasma level (r = 0.42 P = .02) and with 18F-FDG uptake (r = 0.38 P = .05). We did not find any correlation between circulating MMPs and in vivo carotid plaque metabolism assessed by 18F-FDG-PET. After a median follow-up of 1077 days, 4 cerebrovascular, 7 cardiovascular and 11 peripheral vascular events requiring hospitalization were registered. Circulating MMP-7 was capable of predicting events over and above the traditional risk factors (HR = 1.15 P = .006). When the model was associated with the variables of interest, the risk predicted by 18F-FDG-PET was not significant. Conclusions: Circulating MMP-7 may represent a novel marker for recurrent cardiovascular events in patients with moderate to severe carotid stenosis. MMP-7 may reflect the atherosclerotic burden but not plaque inflammation in this specific vascular territory.es_ES
dc.description.sponsorshipStudy recruitment, MMP determinations, PET studies and collection of data sets were supported by grants from the Spanish Research Network on Cerebrovascular Diseases (RETICS-INVICTUS plus -RD12/0014/0009-). The storage and use of human biological samples was partially supported by the Biobank of the Foundation for Applied Medical Research (CIMA), University of Navarra (Pamplona, Spain).es_ES
dc.relationinfo:eu-repo/grantAgreement/MINECO/Redes Temáticas de Investigación Cooperativa en Salud (RETICS)/RD12%2F0014%2F0009/ES/Enfermedades vasculares cerebrales (Ictus)es_ES
dc.subjectCarotid endarterectomyes_ES
dc.subjectMatrix metalloproteinaseses_ES
dc.subjectPositron emission tomographyes_ES
dc.titleElevated circulating metalloproteinase 7 predicts recurrent cardiovascular events in patients with carotid stenosis: a prospective cohort studyes_ES
dc.description.noteThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.es_ES
dadun.citation.publicationNameBMC Cardiovascular Disorderses_ES

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