Full metadata record
DC Field | Value | Language |
---|---|---|
dc.creator | Pinazo-Duran, M.D. (M. Dolores) | - |
dc.creator | Garcia-Medina, J.J. (José Javier) | - |
dc.creator | Bolarín, J.M. (José M.) | - |
dc.creator | Sanz-González, S.M. (Silvia M.) | - |
dc.creator | Valero-Vello, M. (Mar) | - |
dc.creator | Abellán-Abenza, J. (Javier) | - |
dc.creator | Zanón-Moreno, V. (Vicente) | - |
dc.creator | Moreno-Montañes, J. (Javier) | - |
dc.date.accessioned | 2023-05-26T07:18:56Z | - |
dc.date.available | 2023-05-26T07:18:56Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | Pinazo-Duran, M.D. (M. Dolores); Garcia-Medina, J.J. (José Javier); Bolarín, J.M. (José M.); et al. "Computational analysis of clinical and molecular markers and new theranostic possibilities in primary open-angle glaucoma". Journal of clinical medicine. 9 (9), 2020, 3032 | es |
dc.identifier.issn | 2077-0383 | - |
dc.identifier.uri | https://hdl.handle.net/10171/66376 | - |
dc.description.abstract | Primary open-angle glaucoma (POAG) is a paramount cause of irreversible visual disability worldwide. We focus on identifying clinical and molecular facts that may help elucidating the pathogenic mechanisms of the disease. By using ophthalmological approaches (biomicroscopy, ocular fundus, optical coherence tomography, and perimetry) and experimental tests (enzyme-linked immunosorbent assay (ELISA), high performance liquid chromatography (HPLC), and Western blot/immunoblotting) directed to evaluate the oxidative stress, inflammation, apoptosis, and neurodegeneration processes, we gather information to build a network of data to perform a computational bioinformatics analysis. Our results showed strong interaction of the above players and its downstream effectors in POAG pathogenesis. In conclusion, specific risk factors were identified, and molecules involved in multiple pathways were found in relation to anterior and posterior eye segment glaucoma changes, pointing to new theranostic challenges for better managing POAG progression. | es_ES |
dc.description.sponsorship | This research was done, in part, with funding from the Valencia and Pamplona research groups of the Spanish Net of Ophthalmic Pathology “OFTARED” of the Institute of Health Carlos III of the Spanish Government (Madrid). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI AG | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Primary open-angle glaucoma | es_ES |
dc.subject | Pathogenesis | es_ES |
dc.subject | Oxidative stress | es_ES |
dc.subject | Inflammation | es_ES |
dc.subject | Apoptosis | es_ES |
dc.subject | Neurodegeneration | es_ES |
dc.subject | Theranostics | es_ES |
dc.title | Computational analysis of clinical and molecular markers and new theranostic possibilities in primary open-angle glaucoma | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.description.note | This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). | es_ES |
dc.identifier.doi | 10.3390/jcm9093032 | - |
dadun.citation.number | 9 | es_ES |
dadun.citation.publicationName | Journal of clinical medicine | es_ES |
dadun.citation.startingPage | 3032 | es_ES |
dadun.citation.volume | 9 | es_ES |
dc.identifier.pmid | 32967086 | - |
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