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dc.creatorGonzález-Zamora, J. (Jorge)-
dc.creatorHernandez, M. (María)-
dc.creatorRecalde, S. (Sergio)-
dc.creatorBezunartea, J. (Jaione)-
dc.creatorMontoliu-Antón, A. (Ana)-
dc.creatorBilbao-Malavé, V. (Valentina)-
dc.creatorLlorente-González, S. (Sara)-
dc.creatorGarcia-Layana, A. (Alfredo)-
dc.creatorFernandez-Robredo, P. (Patricia)-
dc.date.accessioned2023-06-07T09:50:47Z-
dc.date.available2023-06-07T09:50:47Z-
dc.date.issued2023-
dc.identifier.citationGonzález-Zamora, J. (Jorge); Hernández, M.; Recalde-Maestre, S. (Sergio); et al. "Matrix metalloproteinase 13 is associated with age-related choroidal neovascularization". Antioxidants. 12 (4), 2023, 884es
dc.identifier.issn2076-3921-
dc.identifier.urihttps://hdl.handle.net/10171/66561-
dc.description.abstractAge-related macular degeneration (AMD) is a leading cause of severe vision loss in older individuals in developed countries. Despite advances in our understanding of AMD, its pathophysiology remains poorly understood. Matrix metalloproteinases (MMPs) have been proposed to play a role in AMD development. In this study, we aimed to characterize MMP-13 in AMD. We used retinal pigment epithelial cells, a murine model of laser-induced choroidal neovascularization, and plasma samples from patients with neovascular AMD to conduct our study. Our results show that MMP13 expression significantly increased under oxidative stress conditions in cultured retinal pigment epithelial cells. In the murine model, MMP13 was overexpressed in both retinal pigment epithelial cells and endothelial cells during choroidal neovascularization. Additionally, the total MMP13 levels in the plasma of patients with neovascular AMD were significantly lower than those in the control group. This suggests a reduced diffusion from the tissues or release from circulating cells in the bloodstream, given that the number and function of monocytes have been reported to be deficient in patients with AMD. Although more studies are needed to elucidate the role of MMP13 in AMD, it could be a promising therapeutic target for treating AMD.-
dc.description.sponsorshipThe present work was partially funded by Thea Laboratoires (01/2019), Fundación Jesús Gangoiti Barrera (2021–2022), and a collaborative project with Multiópticas (CUN 2019). Moreover, the work was partially supported by Red Temática de Investigación Cooperativa en Salud: ‘Prevention, Early Detection and Treatment of the Prevalent Degenerative and Chronic Ocular Pathology’ (RD16/0008/0011), Ministerio de Economía y Competitividad, Instituto de Salud Carlos III, Fondo Europeo de Desarrollo Regional, Una manera de hacer Europa, Redes de Investigación Cooperativa Orientadas al Resultado en Salud (RICORS) de Terapias avanzadas (RD21/0017/0027), Enfermedades Inflamatorias (RD21/0002/0010), Ministerio de Ciencia e Innovación, Instituto de Salud Carlos III, NextGeneration EU, Plan de Recuperación, Transformación y Resiliencia, 28029 Madrid, Spain.-
dc.language.isoen-
dc.relationinfo:eu-repo/grantAgreement/MINECO/Ayudas a Redes Temáticas de Investigación Cooperativa RETICS (AE de Salud 2016)/RD16/0008/0011/[ES]/OFTARED-
dc.rightsinfo:eu-repo/semantics/openAccess-
dc.subjectBiomaker-
dc.subjectMatrix metalloproteinase-
dc.subjectAge-related macular degeneration-
dc.subjectOxidative stress-
dc.subjectChoroidal neovascularization-
dc.subjectAngiogenesis-
dc.subjectMacular Degeneration-
dc.subjectBruchs Membrane-
dc.subjectMMP-13-
dc.subjectAngiogenesis-
dc.subjectActivation-
dc.titleMatrix metalloproteinase 13 is associated with age-related choroidal neovascularization-
dc.typeinfo:eu-repo/semantics/article-
dc.description.noteThis article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license-
dc.identifier.doi10.3390/antiox12040884-
dadun.citation.number4-
dadun.citation.publicationNameAntioxidants-
dadun.citation.startingPage884-
dadun.citation.volume12-
dc.identifier.pmid37107259-
dc.identifier.pmid37107259-

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