Genotoxicity of silver nanoparticles
Keywords: 
Silver nanoparticles
Genotoxicity
In vitro
In vivo
Mouse lymphoma assay
Micronucleus test
Chromosome aberration test;
Comet assay
Issue Date: 
2020
Publisher: 
MDPI AG
Project: 
info:eu-repo/grantAgreement/MINECO/Contratos Ramón y Cajal/RYC-2013-14370/ES/RYC-2013-14370
ISSN: 
2079-4991
Note: 
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Citation: 
Rodríguez-Garraus, A. (Adriana); Azqueta, A. (Amaya); Vettorazzi, A. (Ariane); et al. "Genotoxicity of silver nanoparticles". Nanomaterials. 10 (2), 2020, 251
Abstract
Silver nanoparticles (AgNPs) are widely used in diverse sectors such as medicine, food, cosmetics, household items, textiles and electronics. Given the extent of human exposure to AgNPs, information about the toxicological effects of such products is required to ensure their safety. For this reason, we performed a bibliographic review of the genotoxicity studies carried out with AgNPs over the last six years. A total of 43 articles that used well-established standard assays (i.e., in vitro mouse lymphoma assays, in vitro micronucleus tests, in vitro comet assays, in vivo micronucleus tests, in vivo chromosome aberration tests and in vivo comet assays), were selected. The results showed that AgNPs produce genotoxic effects at all DNA damage levels evaluated, in both in vitro and in vivo assays. However, a higher proportion of positive results was obtained in the in vitro studies. Some authors observed that coating and size had an effect on both in vitro and in vivo results. None of the studies included a complete battery of assays, as recommended by ICH and EFSA guidelines, and few of the authors followed OECD guidelines when performing assays. A complete genotoxicological characterization of AgNPs is required for decision-making.

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