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dc.creatorRuberte, A.C. (Ana Carolina)-
dc.creatorAydillo-Miguel, C. (Carlos)-
dc.creatorSharma, A.K. (Arun K.)-
dc.creatorSanmartin-Grijalba, C. (Carmen)-
dc.creatorPlano-Amatriain, D. (Daniel)-
dc.date.accessioned2023-08-16T11:03:02Z-
dc.date.available2023-08-16T11:03:02Z-
dc.date.issued2020-
dc.identifier.citationRuberte, A.C. (Ana Carolina); Aydillo-Miguel, C. (Carlos); Sharma, A.K. (Arun K.); et al. "Vilsmeier reagent, NaHSe and diclofenac acid chloride: one-pot synthesis of a novel selenoindolinone with potent anticancer activity". RSC advances. 10 (63), 2020, 38404 - 38408es
dc.identifier.issn1473-7604-
dc.identifier.urihttps://hdl.handle.net/10171/67133-
dc.description.abstractAn effective and straightforward synthesis of 3-seleno functionalized indolinone (5) involving Vilsmeier reagent is presented. Likewise, a procedure to achieve lactamization of diclofenac with excellent yields by using hydrides is also ascertained. Compound 5 exhibited impressive growth inhibition in most of the cell lines in an NCI-60 panel, particularly towards resistant breast cancer cells.es_ES
dc.description.sponsorshipThe authors thank Dr Hemant Yennawar at the X-ray diffraction facility at Penn State University for the determination of the crystal structure. C. S. and D. P. wish to express their gratitude to PIUNA (refs 2014–26 and 2018–19) and UNED–Pamplona, Fundaci´on Bancaria “La Caixa”, and “Fundaci´on Caja Navarra” for nancial support for the project. A. C. R. acknowledges the support of the Asociaci´on de Amigos de la Universidad de Navarra and Caixabank for PhD fellowshipes_ES
dc.language.isoenges_ES
dc.publisherRoyal Society of Chemistryes_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subject3-seleno functionalized indolinonees_ES
dc.subjectVilsmeier reagentes_ES
dc.titleVilsmeier reagent, NaHSe and diclofenac acid chloride: one-pot synthesis of a novel selenoindolinone with potent anticancer activityes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.description.noteThis article is licensed under a Creative Commons Attribution 3.0 Unported Licence.es_ES
dc.identifier.doi10.1039/d0ra07332f-
dadun.citation.endingPage38408es_ES
dadun.citation.number63es_ES
dadun.citation.publicationNameRSC advanceses_ES
dadun.citation.startingPage38404es_ES
dadun.citation.volume10es_ES
dc.identifier.pmid35517563-

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