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dc.creatorRuberte, A.C. (Ana Carolina)-
dc.creatorGonzález-Gaitano, G. (Gustavo)-
dc.creatorSharma, A.K. (Arun K.)-
dc.creatorAydillo-Miguel, C. (Carlos)-
dc.creatorEncío, I. (Ignacio)-
dc.creatorSanmartin-Grijalba, C. (Carmen)-
dc.creatorPlano-Amatriain, D. (Daniel)-
dc.identifier.citationRuberte, A.C. (Ana Carolina); González-Gaitano, G. (Gustavo); Sharma, A.K. (Arun K.); et al. "New Formulation of a Methylseleno-Aspirin Analog with Anticancer Activity Towards Colon Cancer". International Journal of Molecular Sciences. 21 (23), 2020, 9017es
dc.description.abstractAspirin (ASA) has attracted wide interest of numerous scientists worldwide thanks to its chemopreventive and chemotherapeutic effects, particularly in colorectal cancer (CRC). Incorporation of selenium (Se) atom into ASA has greatly increased their anti-tumoral efficacy in CRC compared with the organic counterparts without the Se functionality, such as the promising antitumoral methylseleno-ASA analog (1a). Nevertheless, the efficacy of compound 1a in cancer cells is compromised due to its poor solubility and volatile nature. Thus, 1a has been formulated with native α-, β- and γ-cyclodextrin (CD), a modified β-CD (hydroxypropyl β-CD, HP-β-CD) and Pluronic F127, all of them non-toxic, biodegradable and FDA approved. Water solubility of 1a is enhanced with β- and HP- β-CDs and Pluronic F127. Compound 1a forms inclusion complexes with the CDs and was incorporated in the hydrophobic core of the F127 micelles. Herein, we evaluated the cytotoxic potential of 1a, alone or formulated with β- and HP- β-CDs or Pluronic F127, against CRC cells. Remarkably, 1a formulations demonstrated more sustained antitumoral activity toward CRC cells. Hence, β-CD, HP-β-CD and Pluronic F127 might be excellent vehicles to improve pharmacological properties of organoselenium compounds with solubility issues and volatile nature.es_ES
dc.description.sponsorshipC.S. and D.P. wish to express their gratitude to PIUNA (2018—19) and UNED—Pamplona, Fundación Bancaria “La Caixa”, and “Fundación Caja Navarra” for financial support for the project.es_ES
dc.subjectColorectal canceres_ES
dc.titleNew Formulation of a Methylseleno-Aspirin Analog with Anticancer Activity Towards Colon Canceres_ES
dc.description.noteThis article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (
dc.editorial.noteMDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations.es_ES
dadun.citation.publicationNameInternational Journal of Molecular Scienceses_ES

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