Urinary metabolomics of phenolic compounds reveals biomarkers of type-2 diabetes within the PREDIMED trial
Keywords: 
Genistein
Mediterranean diet
Chronic disease
Polyphenols
Metabolites
Issue Date: 
2023
Project: 
info:eu-repo/grantAgreeement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020–114022RB-I00/ES/DESARROLLO DE PRODUCTOS DE TOMATE SOSTENIBLES PARA MEJORAR EL EJE MICROBIOTA-INTESTINO-CEREBRO: DE LA GRANJA A LA MESA Y LA SALUD
ISSN: 
0753-3322
Note: 
This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Citation: 
Domínguez-López, I.; Lozano-Castellón, J.; Vallverdú-Queralt, A.; et al. "Urinary metabolomics of phenolic compounds reveals biomarkers of type-2 diabetes within the PREDIMED trial". Biomedicine and pharmacotherapy. 162, 2023, 114703
Abstract
Background: Phenolic compounds have been associated with protective effects against type-2 diabetes (T2D). We used a metabolomics approach to determine urinary phenolic metabolites associated with T2D and fasting plasma glucose.Methods: This case-control study within the PREDIMED trial included 200 participants at high cardiovascular risk, 102 of whom were diagnosed with T2D. A panel of urinary phenolic compounds were analysed using a novel method based on liquid chromatography coupled to mass spectrometry. Multivariate statistics and adjusted logistic regressions were applied to determine the most discriminant compounds and their association with T2D. The relationship between the discriminant phenolic compounds and plasma glucose was assessed using multi - variable linear regressions.Results: A total of 41 phenolic compounds were modeled in the orthogonal projection to latent structures discriminant analysis, and after applying adjusted logistic regressions two were selected as discriminant: dihy- drocaffeic acid (OR=0.22 (CI 95 %: 0.09; 0.52) per 1-SD, p-value=0.021) and genistein diglucuronide (OR=0.72 (CI 95%: 0.59; 0.88) per 1-SD, p-value=0.021). Both metabolites were associated with a lower risk of suffering from T2D, but only dihydrocaffeic acid was inversely associated with plasma glucose (beta=-17.12 (95 % CI:-29.92;-4.32) mg/dL per 1-SD, p-value=0.009). Conclusions: A novel method using a metabolomics approach was developed to analyse a panel of urinary phenolic compounds for potential associations with T2D, and two metabolites, dihydrocaffeic acid and genistein diglucuronide, were found to be associated with a lower risk of this condition.

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