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dc.creatorAranaz-Oroz, P. (Paula)-
dc.creatorNavarro-Herrera, D. (David)-
dc.creatorZabala-Navó, M. (María)-
dc.creatorRomo‐Hualde, A. (Ana)-
dc.creatorLópez-Yoldi, M. (Miguel)-
dc.creatorVizmanos-Pérez, J.L. (José Luis)-
dc.creatorMilagro-Yoldi, F.I. (Fermín Ignacio)-
dc.creatorGonzalez-Navarro, C.J. (Carlos Javier)-
dc.date.accessioned2023-10-18T10:23:04Z-
dc.date.available2023-10-18T10:23:04Z-
dc.date.issued2020-
dc.identifier.citationAranaz-Oroz, P. (Paula); Navarro-Herrera, D. (David); Zabala-Navó, M. (María); et al. "Phenolic compounds reduce the fat content in caenorhabditis elegans by affecting lipogenesis, lipolysis, and different stress responses". Pharmaceuticals. 13 (11), 2020, 355es_ES
dc.identifier.issn1424-8247-
dc.identifier.urihttps://hdl.handle.net/10171/67667-
dc.description.abstractSupplementation with bioactive compounds capable of regulating energy homeostasis is a promising strategy to manage obesity. Here, we have screened the ability of different phenolic compounds (myricetin, kaempferol, naringin, hesperidin, apigenin, luteolin, resveratrol, curcumin, and epicatechin) and phenolic acids (p-coumaric, ellagic, ferulic, gallic, and vanillic acids) regulating C. elegans fat accumulation. Resveratrol exhibited the strongest lipid-reducing activity, which was accompanied by the improvement of lifespan, oxidative stress, and aging, without affecting worm development. Whole-genome expression microarrays demonstrated that resveratrol affected fat mobilization, fatty acid metabolism, and unfolded protein response of the endoplasmic reticulum (UPRER), mimicking the response to calorie restriction. Apigenin induced the oxidative stress response and lipid mobilization, while vanillic acid affected the unfolded-protein response in ER. In summary, our data demonstrates that phenolic compounds exert a lipid-reducing activity in C. elegans through different biological processes and signaling pathways, including those related with lipid mobilization and fatty acid metabolism, oxidative stress, aging, and UPR-ER response. These findings open the door to the possibility of combining them in order to achieve complementary activity against obesity-related disorders.es_ES
dc.description.sponsorshipThis work was performed in the Center for Nutrition Research (University of Navarra) with the financial support of the Government of Navarra (projects number IIM14672.RI1 and PC008/PC063-064/PC027-28), LABORATORIOS CINFA, S.A. and VISCOFAN S.A.es_ES
dc.language.isoenges_ES
dc.publisherMDPI AGes_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectObesityes_ES
dc.subjectBioactive compoundses_ES
dc.subjectResveratroles_ES
dc.subjectApigenines_ES
dc.subjectVanillic acides_ES
dc.titlePhenolic compounds reduce the fat content in caenorhabditis elegans by affecting lipogenesis, lipolysis, and different stress responseses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.description.noteThis article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).es_ES
dc.identifier.doi10.3390/ph13110355-
dadun.citation.number11es_ES
dadun.citation.publicationNamePharmaceuticalses_ES
dadun.citation.startingPage355es_ES
dadun.citation.volume13es_ES
dc.identifier.pmid33143060-

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