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dc.creatorSantos, J.L. (José Luis)-
dc.creatorKrause, B.J. (Bernardo J.)-
dc.creatorCataldo, L.R. (Luis R.)-
dc.creatorVega, J.A. (Javier Andrés)-
dc.creatorSalas-Pérez, F. (Francisca)-
dc.creatorMennickent, P. (Paula)-
dc.creatorGallegos, R. (Raúl)-
dc.creatorMilagro-Yoldi, F.I. (Fermín Ignacio)-
dc.creatorPrieto-Hontoria, P.L. (Pedro L.)-
dc.creatorRiezu-Boj, J.I. (José Ignacio)-
dc.creatorBravo, C. (Carolina)-
dc.creatorSalas-Huetos, A. (Albert)-
dc.creatorArpon, A. (Ana)-
dc.creatorGalgani, J.E. (José E.)-
dc.creatorMartinez, J.A. (José Alfredo)-
dc.date.accessioned2023-10-23T12:53:20Z-
dc.date.available2023-10-23T12:53:20Z-
dc.date.issued2020-
dc.identifier.citationSantos, J.L. (José Luis); Krause, B.J. (Bernardo J.); Cataldo, L.R. (Luis R.); et al. "PPARGC1A gene promoter methylation as a biomarker of insulin secretion and sensitivity in response to glucose challenges". Nutrients. 12 (9), 2020, 2790es
dc.identifier.issn2072-6643-
dc.identifier.urihttps://hdl.handle.net/10171/67698-
dc.description.abstractMethylation in CpG sites of the PPARGC1A gene (encoding PGC1-α) has been associated with adiposity, insulin secretion/sensitivity indexes and type 2 diabetes. We assessed the association between the methylation profile of the PPARGC1A gene promoter gene in leukocytes with insulin secretion/sensitivity indexes in normoglycemic women. A standard oral glucose tolerance test (OGTT) and an abbreviated version of the intravenous glucose tolerance test (IVGTT) were carried out in n = 57 Chilean nondiabetic women with measurements of plasma glucose, insulin, and C-peptide. Bisulfite-treated DNA from leukocytes was evaluated for methylation levels in six CpG sites of the proximal promoter of the PPARGC1A gene by pyrosequencing (positions -816, -783, -652, -617, -521 and -515). A strong correlation between the DNA methylation percentage of different CpG sites of the PPARGC1A promoter in leukocytes was found, suggesting an integrated epigenetic control of this region. We found a positive association between the methylation levels of the CpG site -783 with the insulin sensitivity Matsuda composite index (rho = 0.31; p = 0.02) derived from the OGTT. The CpG hypomethylation in the promoter position -783 of the PPARGC1A gene in leukocytes may represent a biomarker of reduced insulin sensitivity after the ingestion of glucose.es_ES
dc.description.sponsorshipThis research was funded by the Chilean Fondo Nacional de Desarrollo Científico y Tecnológico (FONDECYT project 1150416), the Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition (CIBERobn), Institute of Health Carlos III, Madrid, Spain (CB12/03/30002) and Ministerio de Economía y Competitividad (AGL2013-4554-R).es_ES
dc.language.isoenges_ES
dc.publisherMDPI AGes_ES
dc.relationinfo:eu-repo/grantAgreement/MINECO/Centros de Investigación Biomédica en Red (CIBER)/CB12%2F03%2F30002/ES/INCORPORACION GRUPOS CIBER FISIOPATOLOGIA DE LA OBESIDAD Y NUTRICION (CIBER OBN)es_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectMethylationes_ES
dc.subjectInsulin sensitivityes_ES
dc.subjectInsulin secretiones_ES
dc.subjectBiomarkeres_ES
dc.subjectGene variantes_ES
dc.subjectPPARGC1A genees_ES
dc.titlePPARGC1A gene promoter methylation as a biomarker of insulin secretion and sensitivity in response to glucose challengeses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.description.noteThis article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).es_ES
dc.identifier.doi10.3390/nu12092790-
dadun.citation.number9es_ES
dadun.citation.publicationNameNutrientses_ES
dadun.citation.startingPage2790es_ES
dadun.citation.volume12es_ES
dc.identifier.pmid32933059-

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