The most prominent modulated annexins during parasitic infections
Keywords: 
Área de Biomedicina
Parasite
Malaria
Annexin
Trypanosomiasis
Toxoplasmosis
Leishmaniasis
Therapeutics
Pathogenesis
Issue Date: 
2023
Project: 
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020–112713RB-C21/ES/EMBEDDING OF DRUGS IN POLYMERIC FIBERS FOR DERMAL RELEASE: APPLICATION TO THE TREATMENT OF CUTANEOUS LEISHMANIASIS AND SKIN INFECTIONS
ISSN: 
0001-706X
Note: 
This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/bync-nd/4.0/).
Citation: 
Rashidi, S.; Mansouri, R.; Ali-Hassanzadeh, M.; et al. "The most prominent modulated annexins during parasitic infections". Acta tropica. 243, 2023, 106942
Abstract
Annexins (ANXs) exert different functions in cell biological and pathological processes and are thus known as double or multi-faceted proteins. These sophisticated proteins might express on both parasite structure and secretion and in parasite-infected host cells. In addition to the characterization of these pivotal proteins, describing their mechanism of action can be also fruitful in recognizing their roles in the pathogenesis of parasitic infections. Accordingly, this study presents the most prominent ANXs thus far identified and their relevant functions in parasites and infected host cells during pathogenesis, especially in the most important intracellular protozoan parasitic infections including leishmaniasis, toxoplasmosis, malaria and trypanosomiasis. The data provided in this study demonstrate that the helminth parasites most probably express and secret ANXs to develop pathogenesis while the modulation of the host-ANXs could be employed as a crucial strategy by intracellular protozoan parasites. Moreover, such data highlight that the use of analogs of both parasite and host ANX peptides (which mimic or regulate ANXs physiological functions through various strategies) might suggest novel therapeutic insights into the treatment of parasitic infections. Furthermore, due to the prominent immunoregulatory activities of ANXs during most parasitic infections and the expression levels of these proteins in some parasitic infected tissues, such multifunctional proteins might be also potentially relevant as vaccine and diagnostic biomarkers. We also suggest some prospects and insights that could be useful and applicable to form the basis of future experimental studies.

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