Potential Use of Vivascope for real-time histological evaluation in endoscopic laryngeal surgery
Keywords: 
Área de Medicina Clínica y Epidemiología
Laryngeal dysplasia
Artificial intelligence
Endoscopic laryngeal surgery
Confocal laser scanning microscopy
Issue Date: 
2023
ISSN: 
2075-4426
Note: 
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).
Citation: 
De Benedetto, L.; Moffa, A.; Baptista-Jardín, P. (Peter Michael); et al. "Potential Use of Vivascope for real-time histological evaluation in endoscopic laryngeal surgery". Journal of personalized medicine. 13 (8), 2023, 1252
De Benedetto, L.; Moffa, A.; Baptista-Jardín, P. (Peter Michael); et al. "Potential Use of Vivascope for real-time histological evaluation in endoscopic laryngeal surgery". Journal of personalized medicine. 13 (8), 2023, 1252
Abstract
We aimed to assess the feasibility of using confocal laser scanning microscopy (CLSM) for the real-time ex vivo examination of histological samples of laryngeal lesions and to evaluate the correlation between CLSM and definitive histological results. This preliminary study included eight consecutive patients with suspected laryngeal lesions who were candidates for endoscopic laryngeal surgery. The obtained samples were evaluated using CLSM and classified as inadequate or adequate (high- and low-grade dysplasia, in situ and invasive carcinoma, positive surgical margin, and inflammatory outbreaks). CLSM showed the macro image in all cases and generated a digital version. All the samples were defined as adequate during CLSM and confirmed at histopathology: low-grade dysplasia (n = 5), low- and high-grade dysplasia (n = 2), and high-grade dysplasia (n = 1). Four samples had an involved resection margin, and three samples revealed the presence of inflammatory outbreaks. CLSM can be applied to larynx pathology with excellent agreement with final histological results.

Files in This Item:
Thumbnail
File
pdf.pdf
Description
Size
3.64 MB
Format
Adobe PDF


Statistics and impact

Items in Dadun are protected by copyright, with all rights reserved, unless otherwise indicated.