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dc.creatorVilalta-Lacarra, A. (Anna)-
dc.creatorVilalta-Franch, J. (Joan)-
dc.creatorSerrano-Sarbosa, D. (Domenec)-
dc.creatorMarti-Lluch, R. (Ruth)-
dc.creatorMarrugat, J. (Jaume)-
dc.creatorGarre-Olmo, J. (Josep)-
dc.identifier.citationVilalta-Lacarra, A. (Anna); Vilalta-Franch, J.; Serrano-Sarbosa, D.; et al. "Association of depression phenotypes and antidepressant treatment with mortality due to cancer and other causes: a community-based cohort study". Frontiers In Psichology. 14, 2023, 1192462es
dc.description.abstractObjectiveThis study aimed to assess the association of somatic depressive symptoms (SDS), cognitive/emotional depressive symptoms (C-EDS), and antidepressant treatment on mortality due to cancer and other causes in a community cohort.MethodsA community-based sample recruited in 1995, 2000, and 2005 aged between 35 and 75 years was examined in two waves and followed for a median of 6.7 years. SDS and C-EDS phenotypes were assessed using the Patient Health Questionnaire-9. Medication used by participants was collected. Deaths and their causes were registered during follow-up. Cox proportional hazard models stratified by sex were performed to determine the association between depressive phenotypes and mortality.ResultsThe cohort consisted of 5,646 individuals (53.9% women) with a mean age of 64 years (SD = 11.89). During the follow-up, 392 deaths were recorded, of which 27.8% were due to cancer. C-EDS phenotype was associated with an increased risk of cancer mortality in both men (HR = 2.23; 95% CI = 1.11-4.44) and women (HR = 3.69; 95% CI = 1.69-8.09), and SDS was significantly associated with non-cancer mortality in men (HR = 2.16; 95 CI % = 1.46-3.18). Selective serotonin reuptake inhibitors (SSRIs) were significantly associated with both cancer (HR = 2.78; 95% CI = 1.10-6.98) and non-cancer mortality (HR = 2.94; 95% CI = 1.76-4.90) only in the male population.ConclusionC-EDS phenotype was related to an increased risk of cancer mortality at 6 years. In addition, the use of SSRIs in the male population was associated with cancer and all-cause mortality.-
dc.description.sponsorshipThis study was supported by the research grant STL006/17/00234 from the Strategic Plan for Health Research and Innovation (PERIS) 2016–2020 of the Department of Health, Government of Catalonia. The funding sources played no role in the design and conduct of the study, collection, management, analysis, and interpretation of the data, nor in the preparation, review, or approval of the manuscript.-
dc.subjectÁrea de Medicina Clínica y Epidemiología-
dc.subjectDepressive syndrome-
dc.subjectSomatic symptoms-
dc.subjectAntidepressant drug-
dc.titleAssociation of depression phenotypes and antidepressant treatment with mortality due to cancer and other causes: a community-based cohort study-
dc.description.noteThis is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.-
dadun.citation.publicationNameFRONTIERS IN PSYCHOLOGY-

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