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dc.creatorAsbai-Ghoudan, R. (Reduan)-
dc.creatorNasello, G. (Gabriele)-
dc.creatorPérez, M.A. (María Ángeles)-
dc.creatorVerbruggen, S.W. (Stefaan W.)-
dc.creatorRuiz-de-Galarreta-Moriones, S.(Sergio)-
dc.creatorRodriguez-Florez, N. (Naiara)-
dc.date.accessioned2023-11-14T09:34:29Z-
dc.date.available2023-11-14T09:34:29Z-
dc.date.issued2023-
dc.identifier.citationAsbai-Ghoudan, R. (Reduan); Nasello, G. (Gabriele); Pérez, M.A. (María Ángeles); et al. "In silico assessment of the bone regeneration potential of complex porous scaffolds". Computers in Biology and Medicine. 165, 2023, 107381es
dc.identifier.issn1879-0534-
dc.identifier.urihttps://hdl.handle.net/10171/67845-
dc.description.abstractMechanical environment plays a crucial role in regulating bone regeneration in bone defects. Assessing the mechanobiological behavior of patient-specific orthopedic scaffolds in-silico could help guide optimal scaffold designs, as well as intra- and post-operative strategies to enhance bone regeneration and improve implant longevity. Additively manufactured porous scaffolds, and specifically triply periodic minimal surfaces (TPMS), have shown promising structural properties to act as bone substitutes, yet their ability to induce mechanobiologially-driven bone regeneration has not been elucidated. The aim of this study is to i) explore the bone regeneration potential of TPMS scaffolds made of different stiffness biocompatible materials, to ii) analyze the influence of pre-seeding the scaffolds and increasing the post-operative resting period, and to iii) assess the influence of patient-specific parameters, such as age and mechanosensitivity, on outcomes. To perform this study, an in silico model of a goat tibia is used. The bone ingrowth within the scaffold pores was simulated with a mechano-driven model of bone regeneration. Results showed that the scaffold's architectural properties affect cellular diffusion and strain distribution, resulting in variations in the regenerated bone volume and distribution. The softer material improved the bone ingrowth. An initial resting period improved the bone ingrowth but not enough to reach the scaffold's core. However, this was achieved with the implantation of a pre-seeded scaffold. Physiological parameters like age and health of the patient also influence the bone regeneration outcome, though to a lesser extent than the scaffold design. This analysis demonstrates the importance of the scaffold's geometry and its material, and highlights the potential of using mechanobiological patient-specific models in the design process for bone substitutes.es_ES
dc.description.sponsorshipRAG is grateful for the financial support for an international mobility by Programa de ayudas de movilidad de la Fundacion ´ Bancaria La Caixa. SRG and NRF are grateful for the support by Proyecto de Generacion ´ de Conocimiento (PID2021-126471OA-I00). MAP is grateful for the support by the Spanish Ministry of Science and Innovation Grant No PID2020-113819RB-I00.es_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.relationinfo:eu-repo/grantAgreement/AEI/Proyectos I+D/PID2020-113819RB-I00/[ES]/DISEÑO DE IMPLANTES PARA TERAPIA TUMORAL Y REGENERACION OSEA TRAS RESECCION DE OSTEOSARCOMA MEDIANTE MICROFLUIDICA, IMPRESION 3D Y MODELADO COMPUTACIONAL MULTIESCALAes_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectBone regenerationes_ES
dc.subjectFE-Based modeles_ES
dc.subjectMechanical stimuluses_ES
dc.subjectMechanobiologyes_ES
dc.subjectScaffoldses_ES
dc.subjectTriply periodic minimal surfaceses_ES
dc.titleIn silico assessment of the bone regeneration potential of complex porous scaffoldses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.description.noteThis is an open access article under the CC BY-NC-ND licensees_ES
dc.identifier.doi10.1016/j.compbiomed.2023.107381-
dadun.citation.startingPage107381es_ES
dadun.citation.volume165es_ES
dc.identifier.pmid37611419-

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