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dc.creatorRomero-Torrecilla, J.A. (Juan Antonio)-
dc.creatorLamo-de-Espinosa-Vázquez-de-Sola, J.M. (José María)-
dc.creatorRipalda-Cemboráin, P. (Purificación)-
dc.creatorLópez-Martínez, T. (Tania)-
dc.creatorAbizanda-Sarasa, G. (Gloria)-
dc.creatorRiera-Alvarez, L. (Luis)-
dc.creatorRuiz-de-Galarreta-Moriones, S.(Sergio)-
dc.creatorLópez-Barberena, A. (Asier)-
dc.creatorRodriguez-Florez, N. (Naiara)-
dc.creatorElizalde, R. (Reyes)-
dc.creatorJayawarna, V. (Vineetha)-
dc.creatorValdés-Fernández, J. (José)-
dc.creatorEchanove-González De Anleo, M. (Miguel)-
dc.creatorChilds, P. (Peter)-
dc.creatorJuan-Pardo, E.M. (Elena M.) de-
dc.creatorSalmeron-Sanchez, M. (Manuel)-
dc.creatorProsper-Cardoso, F. (Felipe)-
dc.creatorMuiños-López, E. (Emma)-
dc.creatorGranero-Moltó, F. (Froilán)-
dc.date.accessioned2023-11-15T16:14:15Z-
dc.date.available2023-11-15T16:14:15Z-
dc.date.issued2023-
dc.identifier.citationRomero-Torrecilla, J. (Juan Antonio); Lamo de Espinosa-Vázquez de Sola, J. (José María); Ripalda-Cemboráin, P. (Purificación); et al. "An engineered periosteum for efficient delivery of rhBMP-2 and mesenchymal progenitor cells during bone regeneration". NPJ regenerativa medicine. 8 (1), 2023, 54es
dc.identifier.issn2057-3995-
dc.identifier.urihttps://hdl.handle.net/10171/67857-
dc.description.abstractDuring bone regeneration, the periosteum acts as a carrier for key regenerative cues, delivering osteochondroprogenitor cells and crucial growth factors to the injured bone. We developed a biocompatible, 3D polycaprolactone (PCL) melt electro-written membrane to act as a mimetic periosteum. Poly (ethyl acrylate) coating of the PCL membrane allowed functionalization, mediated by fibronectin and low dose recombinant human BMP-2 (rhBMP-2) (10-25 mu g/ml), resulting in efficient, sustained osteoinduction in vitro. In vivo, rhBMP-2 functionalized mimetic periosteum demonstrated regenerative potential in the treatment of rat critical-size femoral defects with highly efficient healing and functional recovery (80%-93%). Mimetic periosteum has also proven to be efficient for cell delivery, as observed through the migration of transplanted periosteum-derived mesenchymal cells to the bone defect and their survival. Ultimately, mimetic periosteum demonstrated its ability to deliver key stem cells and morphogens to an injured site, exposing a therapeutic and translational potential in vivo when combined with unprecedentedly low rhBMP-2 doses.-
dc.description.sponsorshipThis work was supported by funds of the Ministerio de Ciencia e Investigación through Instituto de Salud Carlos III and European Regional Development Funds (A way to make Europe) (PI17/00136, PI20/00076) to F.G.M. and ISC-RETICS (RD16/0011/ 005) and Next Generation EU, Plan de Recuperación, Transformación y Resiliencia RICORS TERAV ISCIII (RD21/0017/0009) and European Union Horizon 2020 MSCA-RISE (grant agreement #872648, MEPHOS) to F.P., European Union Horizon 2020 program (grant agreement #874889, HEALIKICK) to M.S.S. and F.G.M., EPSRC Programme grant (EP/P001114/1) to M.S.-S. and Departamento de Desarrollo Económico del Gobierno de Navarra (PC009-010-011 and PC073-074-075, 3DMedical) to F.G.M. J.A. RomeroTorrecilla was supported by a fellowship of “Asociación de Amigos de la Universidad de Navarra” and “Obra Social La Caixa”; the research leading to these results received funding from “la Caixa” Banking Foundation. J.V.F. was supported by a fellowship from “Asociación de Amigos de la Universidad de Navarra”, and M.E.G.A. is supported by a CIMA AC fellowship from “Fundación para la Investigación Médica Aplicada”.-
dc.language.isoen-
dc.rightsinfo:eu-repo/semantics/openAccess-
dc.subjectÁrea de Biomedicina-
dc.subjectInduced membrane technique.-
dc.subjectGrowth-factor delivery.-
dc.subjectStem-cells.-
dc.subjectMorphogenetic protein-2.-
dc.subjectBiomimetic periosteum.-
dc.subjectDefects.-
dc.subjectBMP-2-
dc.subjectRat.-
dc.subjectModel-
dc.subjectDifferentiation-
dc.titleAn engineered periosteum for efficient delivery of rhBMP-2 and mesenchymal progenitor cells during bone regeneration-
dc.typeinfo:eu-repo/semantics/article-
dc.relation.publisherversionhttps://pubmed.ncbi.nlm.nih.gov/37773177/-
dc.editorial.noteThis article is licensed under a Creative Commons Attribution 4.0 International License.-
dc.identifier.doi10.1038/s41536-023-00330-2-
dadun.citation.number1-
dadun.citation.publicationNameNPJ regenerative medicine-
dadun.citation.startingPage54-
dadun.citation.volume8-

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