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dc.creatorTomás-Velázquez, A. (Alejandra)-
dc.creatorLópez-Gutiérrez, J.C. (Juan Carlos)-
dc.creatorReyes, M. (Miguel)-
dc.creatorSalgado, C.M. (Claudia M.)-
dc.creatorHervas-Stubbs, S. (Sandra)-
dc.creatorAndrea, C.E. (Carlos Eduardo) de-
dc.creatorBasu, D. (Dipanjan)-
dc.creatorAndrés, E.M. (Eva M.)-
dc.creatorTriana, P. (Paloma)-
dc.creatorCeballos-Rodríguez, C. (Carmen)-
dc.creatorReina, G. (Gabriel)-
dc.creatorRedondo-Bellón, P. (Pedro)-
dc.date.accessioned2023-11-21T09:21:54Z-
dc.date.available2023-11-21T09:21:54Z-
dc.date.issued2023-
dc.identifier.citationTomás-Velázquez, A. (Alejandra); López-Gutiérrez, J.C. (Juan Carlos); Reyes, M. (Miguel); et al. "Serum levels of S-100 protein are directly proportional to the size, number, thickness and degree of cellularity of congenital melanocytic nevi". Journal of the American Academy of Dermatology. 89 (5), 2023, 1074 - 1077es_ES
dc.identifier.issn1097-6787-
dc.identifier.urihttps://hdl.handle.net/10171/67902-
dc.description.abstractTo the Editor: Some patients with congenital melanocytic nevi (CMN) present progressive growth and thickening, extracutaneous involvement (neurocutaneous melanocytosis, NCM) or neoplastic transformation (melanoma); and others remain stable or even regress. There are no markers to assess progression or follow-up. Recently, we found S-100, a protein which acts on cell differentiation and proliferation, elevated in CMN.1 S-100 is a ligand of the RAGE pathway (related to the MAPK-pathway), and low serum levels of soluble-RAGE were related to poor survival in melanoma.2 Also SOX10, expressed in melanocytes with high specificity, is useful in detection, prognosis and treatment assessment of melanoma.3 We explored if S-100, RAGE and SOX10 serum levels vary in children’s CMN and assessed clinical or pathological correlations.es_ES
dc.description.sponsorshipThe research has been partially funded by grants from Fundacion Ramon Areces and Instituto de Salud Carlos III, from Spain; and by the Marjorie K. Harmer endowment for research in Pediatric Pathology (MRM), from US.es_ES
dc.language.isospaes_ES
dc.publisherElsevieres_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectS-100es_ES
dc.subjectBenign skin tumores_ES
dc.subjectBiomarkerses_ES
dc.subjectCongenital melanocytic nevuses_ES
dc.subjectGiant nevuses_ES
dc.subjectMelanomaes_ES
dc.subjectNeurocutaneous melanocytosises_ES
dc.subjectSerumes_ES
dc.subjectSkin neoplasmes_ES
dc.subjectSubcutaneous tissuees_ES
dc.titleSerum levels of S-100 protein are directly proportional to the size, number, thickness and degree of cellularity of congenital melanocytic nevies_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.description.noteThis is an open access article under the CC BY-NC-ND licensees_ES
dc.identifier.doi10.1016/j.jaad.2023.06.059-
dadun.citation.endingPage1077es_ES
dadun.citation.number5es_ES
dadun.citation.publicationNameJournal of the American Academy of Dermatologyes_ES
dadun.citation.startingPage1074es_ES
dadun.citation.volume89es_ES
dc.identifier.pmid37495174-

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