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dc.creatorManrique-Huarte, R. (Raquel)-
dc.creatorGaraycochea, O. (Octavio)-
dc.creatorParilli-Troconis, D. (Daniella)-
dc.creatorPerez-Fernandez, N. (Nicolás)-
dc.creatorManrique, M. (Manuel)-
dc.date.accessioned2023-11-21T09:53:31Z-
dc.date.available2023-11-21T09:53:31Z-
dc.date.issued2023-
dc.identifier.citationManrique-Huarte, R. (Raquel); Garaycochea, O. (Octavio); Parilli-Troconis, D. (Daniella); et al. "Histopathological reaction in the vestibule after cochlear implantation in Macaca fascicularis.". Journal of the Neurological Sciences. 450, 2023, 120672es_ES
dc.identifier.issn1878-5883-
dc.identifier.urihttps://hdl.handle.net/10171/67906-
dc.description.abstractCochlear implantation surgery (CI) is considered a safe procedure and is the standard treatment for the auditory rehabilitation in patients with severe-to-profound sensorineural hearing loss. Although the development of minimally traumatic surgical concepts (MTSC) have enabled the preservation of residual hearing after the implantation, there is scarce literature regarding the vestibular affection following MTCS. The aim of the study is to analyze histopathologic changes in the vestibule after CI in an animal model (Macaca fascicularis). Cochlear implantation was performed successfully in 14 ears following MTCS. They were classified in two groups upon type of electrode array used. Group A (n = 6) with a FLEX 28 electrode array and Group B (n = 8) with HL14 array. A 6-month follow-up was carried out with periodic objective auditory testing. After their sacrifice, histological processing and subsequent analysis was carried out. Intracochlear findings, vestibular presence of fibrosis, obliteration or collapse is analyzed. Saccule and utricle dimensions and neuroepithelium width is measured. Cochlear implantation was performed successfully in all 14 ears through a round window approach. Mean angle of insertion was >270◦ for group A and 180–270◦ for group B. In group A auditory deterioration was observed in Mf 1A, Mf2A and Mf5A with histopathological signs of scala tympani ossification, saccule collapse (Mf1A and Mf2A) and cochlear aqueduct obliteration (Mf5A). Besides, signs of endolymphatic sinus dilatation was seen for Mf2B and Mf5A. Regarding group B, no auditory deterioration was observed. Histopathological signs of endolymphatic sinus dilatation were seen in Mf 2B and Mf 8B. In conclusion, the risk of histological damage of the vestibular organs following minimally traumatic surgical concepts and the soft surgery principles is very low. CI surgery is a safe procedure and it can be done preserving the vestibular structures.es_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectCochlear implantationes_ES
dc.subjectVestibular organses_ES
dc.subjectHistologyes_ES
dc.subjectUtriclees_ES
dc.subjectSacculees_ES
dc.titleHistopathological reaction in the vestibule after cochlear implantation in Macaca fascicularis.es_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.description.noteThis is an open access article under the CC BY-NC-ND licensees_ES
dc.identifier.doi10.1016/j.jns.2023.120672-
dadun.citation.publicationNameJournal of the Neurological Scienceses_ES
dadun.citation.startingPage120672es_ES
dadun.citation.volume450es_ES

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