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dc.creatorToledo, E. (Estefanía)-
dc.creatorWittenbecher, C. (Clemens)-
dc.creatorRazquin, C. (Cristina)-
dc.creatorRuiz-Canela, M. (Miguel)-
dc.creatorClish, C.B. (Clary B.)-
dc.creatorLiang, L. (Liming)-
dc.creatorAlonso, A. (Alvaro)-
dc.creatorHernandez-Alonso, P. (Pablo)-
dc.creatorBecerra-Tomas, N. (Nerea)-
dc.creatorAros, F. (Fernando)-
dc.creatorCorella, D. (Dolores)-
dc.creatorRos, E. (Emilio)-
dc.creatorEstruch, R. (Ramón)-
dc.creatorGarcia-Rodriguez, A. (Antonio)-
dc.creatorFito, M. (Montserrat)-
dc.creatorLapetra, J. (José)-
dc.creatorFiol, M. (Miquel)-
dc.creatorAlonso-Gomez, A. (Ángel)-
dc.creatorSerra-Majem, L. (Luis)-
dc.creatorDeik, A. (Amy)-
dc.creatorSalas-Salvado, J. (Jordi)-
dc.creatorHu, F.B. (Frank B.)-
dc.creatorMartinez-Gonzalez, M.A. (Miguel Ángel)-
dc.identifier.citationToledo, E. (Estefanía); Wittenbecher, C. (Clemens); Razquin, C. (Cristina); et al. "Plasma lipidome and risk of atrial fibrillation: results from the PREDIMED trial". Journal of Physiology and Biochemistry. 79, 2023, 355 - 364es_ES
dc.description.abstractThe potential role of the lipidome in atrial fibrillation (AF) development is still widely unknown. We aimed to assess the association between lipidome profiles of the Prevención con Dieta Mediterránea (PREDIMED) trial participants and incidence of AF. We conducted a nested case-control study (512 incident centrally adjudicated AF cases and 735 controls matched by age, sex, and center). Baseline plasma lipids were profiled using a Nexera X2 U-HPLC system coupled to an Exactive Plus orbitrap mass spectrometer. We estimated the association between 216 individual lipids and AF using multivariable conditional logistic regression and adjusted the p values for multiple testing. We also examined the joint association of lipid clusters with AF incidence. Hitherto, we estimated the lipidomics network, used machine learning to select important network-clusters and AF-predictive lipid patterns, and summarized the joint association of these lipid patterns weighted scores. Finally, we addressed the possible interaction by the randomized dietary intervention.Forty-one individual lipids were associated with AF at the nominal level (p < 0.05), but no longer after adjustment for multiple-testing. However, the network-based score identified with a robust data-driven lipid network showed a multivariable-adjusted ORper+1SD of 1.32 (95% confidence interval: 1.16-1.51; p < 0.001). The score included PC plasmalogens and PE plasmalogens, palmitoyl-EA, cholesterol, CE 16:0, PC 36:4;O, and TG 53:3. No interaction with the dietary intervention was found. A multilipid score, primarily made up of plasmalogens, was associated with an increased risk of AF. Future studies are needed to get further insights into the lipidome role on AF.Current Controlled Trials number, ISRCTN35739639.es_ES
dc.description.sponsorshipOpen Access funding provided thanks to the CRUE-CSIC agreement with Springer Nature. This study was supported by the National Institutes of Health grants R01HL118264 and R01DK102896. The PREDIMED trial (Prevención con Dieta Mediterránea) was supported by the ofcial funding agency for biomedical research of the Spanish government, the Instituto de Salud Carlos III, through the grant coordinated by MAMG for a research network specifcally developed during 2006-2013 for the trial (RTIC RD 06/0045) and a previous grant coordinated by RE (RTIC G03/140) during 2003-2005 and through the Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición and by grants from: the Centro Nacional de Investigaciones Cardiovasculares (CNIC 06/2007); the Fondo de Investigación Sanitaria–Fondo Europeo de Desarrollo Regional (PI04–2239, PI 05/2584, CP06/00100, PI07/0240, PI07/1138, PI07/0954, PI 07/0473, PI10/01407, PI10/02658, PI11/01647, P11/02505, and PI13/00462); the Ministerio de Ciencia e Investigación (AGL-2009–13906-C02 and AGL2010–22319-C03); the Fundación Mapfre 2010, Consejería de Salud de la Junta de Andalucía (PI0105/2007); the Public Health Division of the Department of Health of the Autonomous Government of Catalonia, Generalitat Valenciana (ACOMP06109, GVA-COMP2010–181, GVACOMP2011–151, CS2010-AP-111, and CS2011-AP-042); the Regional Government of Navarra (P27/2011); and the European Union in the frame of the Joint Programming Initiative ‘A Healthy Diet for a Healthy Life’ to the Fatty Acid Metabolism—Interlinking Diet with Cardiometabolic Health (FAME)-consortium (01EA1704). J. Salas-Salvadó, gratefully acknowledges the fnancial support by ICREA under the ICREA Academia programme. C. Wittenbecher was supported by an individual fellowship from the German Research Foundation (DFG).es_ES
dc.subjectAtrial fbrillationes_ES
dc.subjectDietary interventiones_ES
dc.subjectNested case–control studyes_ES
dc.titlePlasma lipidome and risk of atrial fibrillation: results from the PREDIMED triales_ES
dc.description.noteThis article is licensed under a Creative Commons Attribution 4.0 International Licensees_ES
dadun.citation.publicationNameJournal of Physiology and Biochemistryes_ES

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