Association between Circulating Levels of 25-Hydroxyvitamin D3 and Matrix Metalloproteinase-10 (MMP-10) in Patients with Type 2 Diabetes
Keywords: 
25-hydroxyvitamin D3
Matrix metalloproteinase 10
Type 2 diabetes
Diabetic kidney disease
Issue Date: 
2022
Publisher: 
MDPI AG
Project: 
info:eu-repo/grantAgreement/MINECO/Proyectos de investigación en salud (Modalidad proyectos de investigación en salud) (AES 2015)/PI15%2F02111/ES/Estudio clínico y experimental del papel de la MMP-10 en la nefropatía diabética tipo 2
ISSN: 
2072-6643
Editorial note: 
CC BY
Note: 
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).
Citation: 
Abasheva, D. (Daria); Dolcet-Negre, M.M. (Marta M.); Fernández-Seara, M.A. (María A.); et al. "Association between Circulating Levels of 25-Hydroxyvitamin D3 and Matrix Metalloproteinase-10 (MMP-10) in Patients with Type 2 Diabetes". Nutrients. 14 (17), 2022, 3484
Abstract
Background: Matrix metalloproteinase-10 (MMP-10) levels increase progressively starting from early diabetic kidney disease (DKD) stages. Vitamin D3 (vitD3 ) deficit is associated with a higher risk of diabetic microangiopathy. Reduced MMP-10 expression has been observed after exposure to vitD3 . Aim: to assess how vitD3 status is related to MMP-10 levels in patients with Type 2 diabetes (T2D). Methods: 256 patients with T2D were included in this cross-sectional study. Demographic, clinical and serum MMP-10 and 25-hydroxyvitamin D3 (25(OH)D3 ) levels were collected from each patient. The association between MMP-10 and (25(OH)D3 ) levels was assessed using a correlation analysis and fitting a multivariate linear regression model. Results: Serum MMP-10 levels were inversely correlated with circulating 25(OH)D3 (rho = −0.25; p < 0.001). In the subgroup analysis this correlation was significant in patients with DKD (rho = −0.28; p = 0.001) and in subjects with vitD3 deficit (rho = −0.24; p = 0.005). In the regression model adjusted for kidney function, body adiposity, smoking and vitD supplementation MMP-10 levels were 68.7 pg/mL lower in patients with 25(OH)D3 > 20 ng/mL, with respect to ≤20 ng/mL (p = 0.006). Conclusions: vitD3 repletion status is an independent predictor of MMP-10 levels in T2D patients. Perhaps, high 25(OH)D3 values should be targeted in these patients in order to prevent vascular complications.

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