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dc.creatorHeidari, B.S. (Behzad Shiroud)-
dc.creatorMuiños-López, E. (Emma)-
dc.creatorChen, P. (Peilin)-
dc.creatorRuan, R. (Rui)-
dc.creatorVahabli, E. (Ebrahim)-
dc.creatorDavachi, S.M. (Seyed Mohammad)-
dc.creatorGranero-Moltó, F. (Froilán)-
dc.creatorJuan-Pardo, E.M. (Elena M.) de-
dc.creatorZheng, M. (Minghao)-
dc.creatorDoyle, B. (Barry)-
dc.date.accessioned2023-12-20T14:03:11Z-
dc.date.available2023-12-20T14:03:11Z-
dc.date.issued2023-
dc.identifier.citationHeidari, B. S.; Muiños-Lopez, E. (Emma); Chen, P.; et al. "Silane-modified hydroxyapatite nanoparticles incorporated into polydioxanone/poly(lactide-co-caprolactone) creates a novel toughened nanocomposite with improved material properties and in vivo inflammatory responses". Materials today bio. 22, 2023, 100778es
dc.identifier.issn2590-0064-
dc.identifier.urihttps://hdl.handle.net/10171/68134-
dc.description.abstractThe interface tissue between bone and soft tissues, such as tendon and ligament (TL), is highly prone to injury. Although different biomaterials have been developed for TL regeneration, few address the challenges of the TL bone interface. Here, we aim to develop novel hybrid nanocomposites based on poly(p-dioxanone) (PDO), poly (lactide-co-caprolactone) (LCL), and hydroxyapatite (HA) nanoparticles suitable for TL-bone interface repair. Nanocomposites, containing 3-10% of both unmodified and chemically modified hydroxyapatite (mHA) with a silane coupling agent. We then explored biocompatibility through in vitro and in vivo studies using a subcutaneous mouse model. Through different characterisation tests, we found that mHA increases tensile properties, creates rougher surfaces, and reduces crystallinity and hydrophilicity. Morphological observations indicate that mHA nanoparticles are attracted by PDO rather than LCL phase, resulting in a higher degradation rate for mHA group. We found that adding the 5% of nanoparticles gives a balance between the properties. In vitro experiments show that osteoblasts' activities are more affected by increasing the nanoparticle content compared with fibroblasts. Animal studies indicate that both HA and mHA nanoparticles (10%) can reduce the expression of pro inflammatory cytokines after six weeks of implantation. In summary, this work highlights the potential of PDO/ LCL/HA nanocomposites as an excellent biomaterial for TL-bone interface tissue engineering applications.-
dc.description.sponsorshipThe authors also gratefully acknowledge funding from the Australian Research Council (IC170100061) through the Centre for Personalised Therapeutics Technologies, and the Science-Industry PhD Fellowship from the Western Australia Department of Jobs, Tourism, Science and Innovation (awarded to B.S.H.). B.S.H. and B.J.D. are inventors on a patent application (PCT/AU2021/050782) titled “Biocompatible polymer compositions” submitted by The University of Western Australia that covers the material composition described in this work.-
dc.language.isoen-
dc.rightsinfo:eu-repo/semantics/openAccess-
dc.subjectSilane modification-
dc.subjectTendon enthesis-
dc.subjectHydroxyapatite-
dc.subjectNanocomposites-
dc.subjectInterface tissue-
dc.titleSilane-modified hydroxyapatite nanoparticles incorporated into polydioxanone/poly(lactide-co-caprolactone) creates a novel toughened nanocomposite with improved material properties and in vivo inflammatory responses-
dc.typeinfo:eu-repo/semantics/article-
dc.description.noteThis is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/bync-nd/4.0/).-
dc.identifier.doi10.1016/j.mtbio.2023.100778-
dadun.citation.publicationNameMATERIALS TODAY BIO-
dadun.citation.startingPage100778-
dadun.citation.volume22-
dc.identifier.pmid37664796-

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