Experience With Teduglutide in Pediatric Short Bowel Syndrome: First Real-life Data
Materias Investigacion::Ciencias de la Salud::Pediatría
Intestinal adaptation
Intestinal failure
Intestinal growth factors
Parenteral nutrition
Issue Date: 
Wolters Kluwer
Ramos-Boluda, E. (Esther); Redecillas-Ferreiro, S. (Susana); Manrique-Moral, (Oscar); et al. "Experience With Teduglutide in Pediatric Short Bowel Syndrome: First Real-life Data". Journal of Pediatric Gastroenterology and Nutrition. 71 (6), 2020, 734 - 739
Objectives: The aim of the study was to describe the experience with teduglutide of several Spanish hospitals in pediatric patients with SBS (SBS). Methods: Seventeen pediatric patients with intestinal failure associated with SBS were treated with teduglutide. Patients received 0.05 mg kg1 day1 of subcutaneous teduglutide. Patients’ demographics and changes in parenteral nutrition (PN) needs, fecal losses, and citrulline level initially and at 3, 6, and 12 months were collected, as well as any adverse events. Results: Patients were receiving 55 ml kg1 day1 and 33 kcal kg1 day1 of parenteral supplementation on average at baseline (2 patients received only hydroelectrolytic solution). A total of 12/17 patients achieved parenteral independence: 3 patients after 3 months of treatment, 4 patients at 6 months, and 5 after 12 months. One patient discontinued treatment 1 year after the beginning as no changes in parenteral support or fecal losses were obtained. All others decreased their intravenous requirements by 50%. One patient suffered an episode of cholecystitis, and another one with a pre-existing cardiac disease, developed a cardiac decompensation. Conclusions: Teduglutide seems to be a safe and effective treatment in the pediatric SBS population with better results than in the pivotal study as well as in the adult population.

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