Nanomedicines for Pediatric Cancers
Keywords: 
Chemotherapy
Drug delivery systems
Glioma
Leukemia
Liposomes
Nanoparticles
Neuroblastoma
Osteosarcoma
Pediatric cancer
Issue Date: 
2018
Publisher: 
ACS
ISSN: 
1936-0851
Citation: 
Rodriguez-Nogales, C. (Carlos); González-Fernández, Y. (Yolanda); Aldaz, A. (Azucena); et al. "Nanomedicines for Pediatric Cancers". ACS nano. 12 (8), 2018, 7482 - 7496
Abstract
Chemotherapy protocols for childhood cancers are still problematic due to the high toxicity associated with chemotherapeutic agents and incorrect dosing regimens extrapolated from adults. Nanotechnology has demonstrated significant ability to reduce toxicity of anticancer compounds. Improvement in the therapeutic index of cytostatic drugs makes this strategy an alternative to common chemotherapy in adults. However, the lack of nanomedicines specifically for pediatric cancer care raises a medical conundrum. This review highlights the current state and progress of nanomedicine in pediatric cancer and discusses the real clinical challenges and opportunities.

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