Effect of a 3-year lifestyle intervention on telomere length in participants from PREDIMED-Plus: A randomized trial
Mediterranean diet
Calorie restriction
Telomere length
Physical activity
Randomized controlled trial
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info:eu-repo/grantAgreement/MICINN/Centros de Investigación Biomédica en Red (CIBER)/ CB07/03/2004/ES/Obesidad y nutrición
This is an open access article under the CC BY-NC-ND license
Marti-del-Moral, A. (Amelia); Fernández-de-la-Puente, M. (María); Canudas, Silvia (S.); et al. "Effect of a 3-year lifestyle intervention on telomere length in participants from PREDIMED-Plus: A randomized trial". Clinical Nutrition. 42 (9), 2023, 1581 - 1587
Background & aims: Short telomeres have been observed in chronic disease patients. Identifying envi- ronmental and lifestyle factors that could reduce telomere attrition is crucial for disease prevention. The aim of this work was to determine whether weight-loss induced by an energy-reduced Mediterranean diet (erMedDiet) and physical activity (PA) could modify telomere length (TL). Methods: In 317 randomized non-smoker participants (mean age, 65.8 ± 4.98 years) with metabolic syndrome from two “Prevenci on con Dieta Mediterr anea-Plus” (PREDIMED-Plus) trial centers, we evaluated MedDiet adherence, PA, anthropometric variables and TL at baseline and after a 3-year intervention using an intensive lifestyle program (IG) with an erMedDiet and PA or an unrestricted MedDiet without PA promotion (CG). Results: Participants in the IG displayed greater 3-year weight reductions ( 3.7 ± 4 kg, P < 0.001) compared to those in the CG. No differences in TL changes between groups were observed in the cohort as a whole. However, an interaction was observed between the intervention group and sex for TL changes (pinteraction ¼ 0.039). Women in the IG showed an increase in TL after 3-y (þ0.25 ± 0.9, relative units) compared to women in the CG ( 0.07 ± 1.0) (p ANCOVA ¼ 0.036), whereas no differences between groups were observed in men. Women in the IG had a lower risk of telomere shortening after the intervention (OR ¼ 0.17, 95%CI: 0.05e0.64, p ¼ 0.008) compared to women in the CG. Conclusions: A 3-year lifestyle intervention based on an erMedDiet and PA slowed telomere shortening in women but not in men.

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