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dc.creatorDiaz-Lagares, A. (Ángel)-
dc.creatorAlegre-Martinez, E. (Estibaliz)-
dc.creatorArroyo, A. (Ainhoa)-
dc.creatorGonzalez-Cao, M. (María)-
dc.creatorZudaire, M.E. (Maria E.)-
dc.creatorViteri, S. (S.)-
dc.creatorMartin-Algarra, S. (Salvador)-
dc.creatorGonzález, Á. (Álvaro)-
dc.date.accessioned2024-01-24T15:04:00Z-
dc.date.available2024-01-24T15:04:00Z-
dc.date.issued2011-
dc.identifier.citationDiaz-Lagares, A. (Ángel); Alegre-Martinez, E. (Estibaliz); Arroyo, A. (Ainhoa); et al. "Evaluation of multiple serum markers in advanced melanoma". Tumor Biology. 32 (6), 2011, 1155 - 1161es
dc.identifier.issn1423-0380-
dc.identifier.urihttps://hdl.handle.net/10171/68527-
dc.description.abstractThe aim of this retrospective study was to analyse in advanced melanoma the potential tumor markers S-100B, melanoma inhibiting activity protein (MIA) and YKL-40 compared to LDH. Serum levels of S-100B, MIA, LDH and YKL-40 were measured in 110 patients with advanced melanoma (36 in stage IIIB/C and 74 in stage IV), in 66 disease-free patients and in 65 healthy controls. Results show that S-100B, MIA and LDH levels were significantly higher in patients with advanced melanoma than in disease-free patients or healthy controls. The combination of S-100B plus MIA had the best diagnostic sensitivity, and the addition of LDH did not further increase this sensitivity. MIA was an independent prognostic factor of overall survival. Patients with both S-100B and MIA elevated had a significant shorter survival than those with both S-100B and MIA under the cut-off. YKL-40 levels did not differentiate patients with advanced melanoma from controls. We concluded that the combination of MIA plus S-100B showed a better prognostic value in advanced melanoma compared to LDH.es_ES
dc.description.sponsorshipA.D.L is funded by the Xunta de Galicia through a research-staff contract “Angeles Alvariño”.es_ES
dc.language.isoenges_ES
dc.publisherSpringeres_ES
dc.rightsinfo:eu-repo/semantics/closedAccesses_ES
dc.subjectMelanomaes_ES
dc.subjectTumour markerses_ES
dc.subjectS-100Bes_ES
dc.subjectMIAes_ES
dc.subjectLDHes_ES
dc.subjectSurvivales_ES
dc.subjectMetastasises_ES
dc.titleEvaluation of multiple serum markers in advanced melanomaes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.identifier.doi10.1007/s13277-011-0218-x-
dadun.citation.endingPage1161es_ES
dadun.citation.number6es_ES
dadun.citation.publicationNameTumor Biologyes_ES
dadun.citation.startingPage1155es_ES
dadun.citation.volume32es_ES
dc.identifier.pmid21858537-

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